Rapid detection of t(15;17)(q24;q21) in acute promyelocytic leukaemia by microwave-assisted fluorescence in situ hybridization

被引：5

作者：

Soriani, Silvia ^{[1
]}

Mura, Cinzia ^{[1
]}

Panico, Anna Rita ^{[1
]}

Scarpa, Anna Maria ^{[1
]}

Recchimuzzo, Patrizia ^{[1
]}

Dadati, Raffaella ^{[1
]}

Farioli, Renata ^{[2
]}

De Canal, Gabriella ^{[1
]}

Mura, Maria Angela ^{[1
]}

Cesana, Clara ^{[1
]}

机构：

[1] Osped Niguarda Ca Granda, Dept Lab Med, Piazza Osped Maggiore 3, I-20162 Milan, Italy

[2] Osped Niguarda Ca Granda, Dept Hematol, Milan, Italy

来源：

HEMATOLOGICAL ONCOLOGY | 2017年 / 35卷 / 01期

关键词：

acute promyelocytic leukaemia; fluorescence in situ hybridization; microwave oven;

D O I：

10.1002/hon.2194

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukaemia (APL) is a hematologic malignancy characterized by the rearrangement of the PML and RAR genes, mostly due to a reciprocal chromosomal translocation t(15;17)(q24;q21). A quick APL diagnosis is essential for starting a prompt suitable therapy. We describe a new rapid diagnostic laboratory approach to detect the PML-RAR rearrangement, which gives clear genetic results within 30min of hybridization. It combines quick cell harvesting, fluorescence in situ hybridization performed with commercial DNA probe and microwave beams supplied by a domestic microwave oven. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：94 / 100

页数：7

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