Inhibitory effects of lapachol derivatives on Epstein-Barr virus activation

被引：78
|
作者：
Sacau, EP
Estévez-Braun, A
Ravelo, AG
Ferro, EA
Tokuda, H
Mukainaka, T
Nishino, H
机构：
[1] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, E-38206 Tenerife, Spain
[2] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 602, Japan
[3] Univ Asuncion, Dept Fitoquim, Asuncion, Paraguay
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 04期
关键词：
D O I：
10.1016/S0968-0896(02)00542-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sixteen derivatives (2-17) synthesized from the naphthoquinone lapachol (1), were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. They exhibited a variety of inhibitory activities from very high to moderate, which allow us to suggest structure-activity relationships. Ten of these derivatives are reported for the first time, their structures being thoroughly determined by spectroscopic methods. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：483 / 488
页数：6
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