A structural-energetic basis for B-cell epitope prediction

被引：9
|
作者：
Caoili, Salvador Eugenio C. [1 ]
机构：
[1] Univ Philippines, Coll Med, Dept Biochem & Mol Biol, Manila 1000, Philippines
来源：
PROTEIN AND PEPTIDE LETTERS | 2006年 / 13卷 / 07期
关键词：
b-cell epitope prediction; antipeptide antibody; antiprotein antibody; peptide-protein cross-reactivity; structural energetics; solvent-accessible surface area;
D O I：
10.2174/092986606777790502
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the development of peptide-based vaccines and immunodiagnostics.
引用
收藏
页码：743 / 751
页数：9
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