Three-component coupling reactions in ionic liquids: An improved protocol for the synthesis of 1,4-dihydropyridines

被引：79
|
作者：
Yadav, JS [1 ]
Reddy, BVS [1 ]
Basak, AK [1 ]
Narsaiah, AV [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
GREEN CHEMISTRY | 2003年 / 5卷 / 01期
关键词：
D O I：
10.1039/b210017g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three-component condensation of aldehyde, beta-ketoester and methyl 3-aminocrotonate proceeds smoothly in 1-n-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4 or 1-n-butyl-3-methylimidazolium hexafluorophosphate [bmim]PF6 ionic liquids at room temperature under mild conditions to afford the corresponding 1,4-dihydropyridine derivatives in high yields. The recovered activated ionic liquids are recycled for four to five runs with no loss in activity.
引用
收藏
页码：60 / 63
页数：4
相关论文
共 50 条
  • [1] A new three-component domino synthesis of 1,4-dihydropyridines
    Sridharan, Vellaisamy
    Perumal, Paramasivan T.
    Avendano, Carmen
    Menendez, J. Carlos
    [J]. TETRAHEDRON, 2007, 63 (21) : 4407 - 4413
  • [2] One-Pot Three-Component Synthesis of Hantzsch 1,4-Dihydropyridines Promoted by Dimethyl Phosphate Ionic Liquids
    Priede, Elina
    Zicmanis, Andris
    [J]. HELVETICA CHIMICA ACTA, 2015, 98 (08) : 1095 - 1103
  • [3] Synthesis of polysubstituted 1,4-dihydropyridines via three-component reaction
    Balalaie, Saeed
    Baoosi, Leila
    Tahoori, Fatemeh
    Rominger, Frank
    Bijanzadeh, Hamid Reza
    [J]. TETRAHEDRON, 2013, 69 (02) : 738 - 743
  • [4] Three-component coupling reactions in ionic liquids:: a facile synthesis of α-aminonitriles
    Yadav, JS
    Reddy, BVS
    Eshwaraiah, B
    Srinivas, M
    Vishnumurthy, P
    [J]. NEW JOURNAL OF CHEMISTRY, 2003, 27 (03) : 462 - 465
  • [5] Organocatalysed three-component domino synthesis of 1,4-dihydropyridines under solvent free conditions
    Kumar, Atul
    Maurya, Ram Awatar
    [J]. TETRAHEDRON, 2008, 64 (16) : 3477 - 3482
  • [6] ONE-POT, THREE-COMPONENT SYNTHESIS OF 1,4-DIHYDROPYRIDINES IN PEG-400
    Wang, Xicun
    Gong, Haipeng
    Quan, Zhengjun
    Li, Lei
    Ye, Helin
    [J]. SYNTHETIC COMMUNICATIONS, 2011, 41 (21) : 3251 - 3258
  • [7] Ionic liquids, metal oxide nanoparticles, and enzymes in synthesis of 1,4-dihydropyridines
    Pajuste, Klavs
    Plotniece, Aiva
    [J]. CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2016, 52 (08) : 538 - 540
  • [8] One-step, three-component synthesis of pyridines and 1,4-dihydropyridines with manifold medicinal utility
    Evdokimov, NM
    Magedov, IV
    Kireev, AS
    Kornienko, A
    [J]. ORGANIC LETTERS, 2006, 8 (05) : 899 - 902
  • [9] SYNTHESIS OF 1,4-DIHYDROPYRIDINES BY CYCLOCONDENSATION REACTIONS
    SAUSINS, A
    DUBURS, G
    [J]. HETEROCYCLES, 1988, 27 (01) : 269 - 289
  • [10] SYNTHESIS OF 1,4-DIHYDROPYRIDINES IN THE CYCLOCONDENSATION REACTIONS
    SAUSINSH, AE
    DUBURS, GY
    [J]. KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1992, (04): : 435 - 467
12345