One-Pot Three-Component Synthesis of Hantzsch 1,4-Dihydropyridines Promoted by Dimethyl Phosphate Ionic Liquids

被引：7

作者：

Priede, Elina ^{[1
]}

Zicmanis, Andris ^{[1
]}

机构：

[1] Univ Latvia, Fac Chem, LV-1586 Riga, Latvia

来源：

HELVETICA CHIMICA ACTA | 2015年 / 98卷 / 08期

关键词：

Hantzsch; 1; 4-dihydropyridines; Dimethyl phosphate; Ionic liquids; Three-component reactions; SOLVENT-FREE SYNTHESIS; EFFICIENT SYNTHESIS; POLYHYDROQUINOLINE DERIVATIVES; PYRIDINE CONDENSATION; AROMATIC-ALDEHYDES; HYDROGEN SULFATE; CATALYST; DIHYDROPYRIDINES; BENZALDEHYDES; REDUCTION;

D O I：

10.1002/hlca.201500009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot three-component reaction of ethyl acetoacetate, AcONH4, and different aldehydes has been successfully performed in the presence of ionic liquids (ILs) possessing a (MeO)(2)PO2- counterion. The impact of electronic and steric effects of the substituents of aromatic aldehydes, as well as the influence of different anions of ILs on the product yield, have been investigated. The application of dimethyl phosphate ILs in the synthesis of Hantzsch 1,4-dihydropyridines presents a simple method for obtaining structurally diverse products in moderate to high yields without using any additional catalyst.

引用

页码：1095 / 1103

页数：9

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