INTERACTION OF WATER-SOLUBLE CELLULOSE DERIVATIVES WITH MUCIN

被引：0

作者：

Mazoniene, Edita ^{[1
]}

Joceviciute, Simona ^{[1
]}

Kazlauske, Jurgita ^{[1
]}

Liesiene, Jolanta ^{[1
]}

Niemeyer, Bernd

机构：

[1] Kaunas Univ Technol, LT-50254 Kaunas, Lithuania

来源：

POLYMER CHEMISTRY AND TECHNOLOGY | 2009年

关键词：

MUCOADHESIVE;

D O I：

暂无

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Mucoadhesivity of cationic derivatives of cellulose is an important factor, when testing their suitability for controlled drug delivery systems. For this purpose, the interaction of hydroxyethylcellulose (HEC), as well as tertiary amino derivative of HEC, with lyophilized mucin was investigated by means of turbidimetric titration, microscopy and measurement of zeta potential and particle size changes in the system. The cationic derivative exhibited distinct mucoadhesive properties, while the interaction of HEC with mucin was much weaker. A possible mechanism of the interaction is discussed.

引用

页码：182 / 186

页数：5

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