Ibogaine selectively inhibits nicotinic receptor-mediated catecholamine release

被引：12
|
作者：
Schneider, AS
Nagel, JE
Mah, SJ
机构：
[1] Dept. of Pharmacol. and Neuroscience, Albany Medical College, Albany
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 317卷 / 2-3期
关键词：
ibogaine; catecholamine release; nicotinic acetylcholine receptor;
D O I：
10.1016/S0014-2999(96)00815-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of ibogaine, a putative anti-addictive drug, on stimulated catecholamine release were examined in cultured chromaffin cells to clarify its mechanism(s) of action. Low concentrations of ibogaine (1-10 mu M) had a selective inhibitory action on nicotinic receptor-mediated catecholamine release, while higher concentrations (100 mu M) inhibited additional modes of stimulated catecholamine release. These results suggest a selective inhibitory action of ibogaine at the nicotinic acetylcholine receptor, possibly at the receptor ion channel site.
引用
收藏
页码：R1 / R2
页数：2
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