Terminal complement without C5 convertase? comment

被引：3
|
作者：
Roumenina, Lubka T. [1 ]
机构：
[1] Ctr Rech Cordeliers, Paris, France
来源：
BLOOD | 2021年 / 137卷 / 04期
关键词：
D O I：
10.1182/blood.2020010133
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Mannes et al have identified a "C3 bypass" activation of the complement component C5.(1) On highly opsonized surfaces, the cell-killing membrane attack complex (MAC) may be formed without a C5 convertase, because of a conformational change in C5, which adopts a C5b-like structure. These findings may explain why C5 inhibitors do not always prevent residual C5 activity in patients with massive complement activation.
引用
收藏
页码：431 / 432
页数：2
相关论文
共 50 条
  • [21] Mouse complement component C4 is devoid of classical pathway C5 convertase subunit activity
    Ebanks, RO
    Isenman, DE
    [J]. MOLECULAR IMMUNOLOGY, 1996, 33 (03) : 297 - 309
  • [22] TRYPANOSOMA-LEWISI - RESTRICTION OF ALTERNATIVE COMPLEMENT PATHWAY C3/C5 CONVERTASE ACTIVITY
    STURTEVANT, JE
    BALBER, AE
    [J]. EXPERIMENTAL PARASITOLOGY, 1987, 63 (03) : 260 - 271
  • [23] ACTIVATION OF THE 5TH COMPONENT OF HUMAN-COMPLEMENT (C5) INDUCED BY MONOSODIUM URATE CRYSTALS - C5 CONVERTASE ASSEMBLY ON THE CRYSTAL-SURFACE
    RUSSELL, IJ
    MANSEN, C
    KOLB, LM
    KOLB, WP
    [J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1982, 24 (02): : 239 - 250
  • [24] Structural studies of convertases in the complement system. The properdin-stabilised proconvertase, and the C5 convertase
    Gadeberg, Trine A. F.
    Pedersen, Dennis Vestergaard
    Andersen, Gregers Rom
    [J]. MOLECULAR IMMUNOLOGY, 2017, 89 : 198 - 198
  • [25] A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity
    Pedersen, Henrik
    Jensen, Rasmus K.
    Jensen, Jens Magnus B.
    Fox, Rachel
    Pedersen, Dennis, V
    Olesen, Heidi G.
    Hansen, Annette G.
    Christiansen, Dorte
    Mazarakis, Sofia M. M.
    Lojek, Neal
    Hansen, Pernille
    Gadeberg, Trine A. F.
    Zarantonello, Alessandra
    Laursen, Nick S.
    Mollnes, Tom Eirik
    Johnson, Matthew B.
    Stevens, Beth
    Thiel, Steffen
    Andersen, Gregers R.
    [J]. JOURNAL OF IMMUNOLOGY, 2020, 205 (08): : 2287 - 2300
  • [26] Morphofunctional Effects of C5 Convertase Blockade in Immune Complex-Mediated Membranoproliferative Glomerulonephritis: Report of Two Cases with Evidence of Terminal Complement Activation
    Carrara, Camillo
    Podesta, Manuel Alfredo
    Abbate, Mauro
    Rizzo, Paola
    Piras, Rossella
    Alberti, Marta
    Daina, Erica
    Ruggenenti, Piero
    Remuzzi, Giuseppe
    [J]. NEPHRON, 2020, 144 (04) : 195 - 203
  • [27] Overexpression of complement C5 in endometriosis
    Aslan, Cigdem
    Ak, Handan
    Askar, Niyazi
    Ozkaya, Ali Burak
    Ergenoglu, Ahmet Mete
    Yeniel, Ahmet Ozgur
    Akdemir, Ali
    Aydin, Hikmet Hakan
    [J]. CLINICAL BIOCHEMISTRY, 2014, 47 (06) : 496 - 498
  • [28] Activation of complement component C5 - Comparison of C5 convertases of the lectin pathway and the classical pathway of complement
    Rawal, Nenoo
    Rajagopalan, Rema
    Salvi, Veena P.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (12) : 7853 - 7863
  • [29] C5 convertase of the alternative pathway of complement - Kinetic analysis of the free and surface-bound forms of the enzyme
    Rawal, N
    Pangburn, MK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (27) : 16828 - 16835
  • [30] C5 convertase of the alternative pathway of complement: Enzymatic properties of the free and surface-bound forms of the enzyme
    Rawal, N
    Pangburn, MK
    [J]. MOLECULAR IMMUNOLOGY, 1998, 35 (6-7) : 392 - 392
12345