Terminal complement without C5 convertase? comment

被引：3
|
作者：
Roumenina, Lubka T. [1 ]
机构：
[1] Ctr Rech Cordeliers, Paris, France
来源：
BLOOD | 2021年 / 137卷 / 04期
关键词：
D O I：
10.1182/blood.2020010133
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Mannes et al have identified a "C3 bypass" activation of the complement component C5.(1) On highly opsonized surfaces, the cell-killing membrane attack complex (MAC) may be formed without a C5 convertase, because of a conformational change in C5, which adopts a C5b-like structure. These findings may explain why C5 inhibitors do not always prevent residual C5 activity in patients with massive complement activation.
引用
收藏
页码：431 / 432
页数：2
相关论文
共 50 条
  • [1] Plasmin as a complement C5 convertase
    Leung, Lawrence L.
    Morser, John
    [J]. EBIOMEDICINE, 2016, 5 : 20 - +
  • [2] Structure and function of complement C5 convertase enzymes
    Pangburn, MK
    Rawal, N
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2002, 30 : 1006 - 1010
  • [3] The C5 Convertase Is Not Required for Activation of the Terminal Complement Pathway in Murine Experimental Cerebral Malaria
    Ramos, Theresa N.
    Darley, Meghan M.
    Weckbach, Sebastian
    Stahel, Philip F.
    Tomlinson, Stephen
    Barnum, Scott R.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (29) : 24734 - 24738
  • [4] Functional role of the noncatalytic subunit of complement C5 convertase
    Rawal, N
    Pangburn, MK
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (03): : 1379 - 1385
  • [5] C3/C5 convertase of the lectin pathway of complement
    Rawal, N
    [J]. MOLECULAR IMMUNOLOGY, 2004, 41 (2-3) : 300 - 300
  • [6] THE INHIBITORY EFFECT OF ROSMARINIC ACID ON COMPLEMENT INVOLVES THE C5 CONVERTASE
    PEAKE, PW
    PUSSELL, BA
    MARTYN, P
    TIMMERMANS, V
    CHARLESWORTH, JA
    [J]. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1991, 13 (07): : 853 - 857
  • [7] Formation of high affinity C5 convertase of the classical pathway of complement
    Rawal, N
    Pangburn, MK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) : 38476 - 38483
  • [8] Thrombin as a C5 convertase
    Zetoune, FS
    Sarma, JV
    Rittirsch, D
    Lambris, JD
    McGuire, SR
    Ward, PA
    [J]. FASEB JOURNAL, 2006, 20 (04): : A641 - A641
  • [9] STRUCTURE OF C5 CONVERTASE
    KINOSHITA, T
    KOZONO, H
    TAKEDA, J
    HONG, K
    KANEKO, M
    PRAMOONJAGO, P
    INOUE, K
    [J]. FASEB JOURNAL, 1988, 2 (06): : A1644 - A1644
  • [10] THE CONVERSION OF HUMAN-COMPLEMENT COMPONENT C5 INTO FRAGMENT C5B BY THE ALTERNATIVE-PATHWAY C5 CONVERTASE
    DISCIPIO, RG
    [J]. BIOCHEMICAL JOURNAL, 1981, 199 (03) : 497 - 504
12345