Reduction of carcinogenic chromium(VI) on the skin of living rats

被引：23
|
作者：
Liu, KJ [1 ]
Mader, K [1 ]
Shi, XL [1 ]
Swartz, HM [1 ]
机构：
[1] NIOSH,PATHOL & PHYSIOL RES BRANCH,MORGANTOWN,WV
来源：
MAGNETIC RESONANCE IN MEDICINE | 1997年 / 38卷 / 04期
关键词：
chromium; in vivo EPR; skin;
D O I：
10.1002/mrm.1910380403
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The reduction of chromate (Cr(VI)) on the skin of living rats was investigated using the technique of in vivo electron paramagnetic resonance (EPR) spectroscopy with a surface coil resonator. Topical application of aqueous solution of Cr(VI) on the skin of rats generated the transient species, Cr(V). Partial removal of the stratum corneum increased the rates of formation and decay of Cr(V), as well as Cr(V) signal intensity. The results demonstrate that skin represents one route for chromium to enter into animals and humans. The generation of reactive Cr(V) species in the reduction of Cr(VI) by the skin may play an important role in the mechanism of Cr(VI)-induced skin cancer. These findings indicate the potential for in vivo EPR spectroscopy for studying the metabolism of paramagnetic reactive species in chemical and biochemical reactions occurring in/on the skin of both smalt and large animals, and possibly humans.
引用
收藏
页码：524 / 526
页数：3
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