Biomimetic oxidation of chromium(III): Does the antidiabetic activity of chromium(III) involve carcinogenic chromium(VI)?

被引：67
|
作者：
Mulyani, I [1 ]
Levina, A [1 ]
Lay, PA [1 ]
机构：
[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 34期
关键词：
bioinorganic chemistry; biological activity; chromium; enzyme inhibitors; oxidation;
D O I：
10.1002/anie.200460113
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The insulin-enhancing activities of some CrIII complexes, such as [Cr3O(OCOEt)6-(OH2)3]+ (1), previously attributed to specific interactions of CrIII ions with cellular insulin receptors, are more likely to be caused by the formation of [CrO4]2- (2). Oxidation of 1 to 2 by biologically relevant oxidants, including enzymes (see scheme), and inhibition of an isolated protein tyrosine phosphatase by a CrVI complex are reported.
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页码：4504 / 4507
页数：4
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