Highly oxygenated flavonoids from Murraya paniculata

Eight highly oxygenated flavones, including one new compound, were isolated from the leaves of an Indonesian medicinal plant, Murraya paniculata. Seven of them were identified as 5-hydroxy-6,7,8,3',4',5'-hexamethoxyflavone (gardenin A), 5,3'-dihydroxy-6,7,8,4',5'-pentamethoxyflavone (gardenin C), 6,7,8,4'-tetramethoxy-5,3',5'-trihydroxyflavone (gardenin E), 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (5-O-desmethylnobiletin), 6,7,8,3',4',5'-hexamethoxyflavone, 5-hydroxy-6,7,3',4',5'-pentamethoxyflavone (umhengerin), 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone either by direct comparison with authentic samples or by comparing their melting points and spectroscopic data with those reported in the literature. The new compound was elucidated as 5,3',5/-trihydroxy-6,7,4'-trimethoxyflavone on the basis of chemical and spectroscopic studies.