Efficient synthesis of phosphorus-containing dendrimers capped with isosteric functions of amino-bismethylene phosphonic acids

被引：30
|
作者：
Rolland, Olivier [1 ,2 ]
Turrin, Cedric-Olivier [1 ,2 ]
Bacquet, Gerard [3 ]
Poupot, Remy [4 ]
Poupot, Mary [4 ]
Caminade, Anne-Marie [1 ,2 ]
Majoral, Jean-Pierre [1 ,2 ]
机构：
[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse, France
[2] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France
[3] Ctr Rech Aubervilliers, F-93308 Aubervilliers, France
[4] Hop Purpan, Ctr Physiopathol Toulouse Purpan, INSERM 563, F-31024 Toulouse 03, France
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 18期
关键词：
Dendrimers; Phosphonate; Sulfonate; Carboxylate; Polyanions; HUMAN MONOCYTES; ACTIVATION; DESIGN; HIV;
D O I：
10.1016/j.tetlet.2009.02.127
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthetic strategy to synthesize phosphorus-containing dendrimers capped with isosteric acid functions derived from tyramine is described. The method is demonstrated on a first generation dendrimer that can be easily capped with 12 amino(bismethylene) sulfonic acids and amino(bismethylene) carboxylic acids that are strict analogs of the corresponding amino(bismethylene) phosphonic acids. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2078 / 2082
页数：5
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