Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial

被引：7

作者：

Brown, Justin C. ^{[1
,2
,3
]}

Rosenthal, Michael H. ^{[4
,5
]}

Ma, Chao ^{[4
,5
]}

Zhang, Sui ^{[4
,5
]}

Nimeiri, Halla S. ^{[6
]}

McCleary, Nadine J. ^{[4
,5
]}

Abrams, Thomas A. ^{[4
,5
]}

Yurgelun, Matthew B. ^{[4
,5
]}

Cleary, James M. ^{[4
,5
]}

Rubinson, Douglas A. ^{[4
,5
]}

Schrag, Deborah ^{[4
,5
]}

Bullock, Andrea J. ^{[7
]}

Allen, Jill ^{[8
]}

Zuckerman, Dan ^{[9
]}

Chan, Emily ^{[10
]}

Chan, Jennifer A. ^{[4
,5
]}

Wolpin, Brian ^{[4
,5
]}

Constantine, Michael ^{[11
]}

Weckstein, Douglas J. ^{[12
]}

Faggen, Meredith A. ^{[13
]}

Thomas, Christian A. ^{[14
]}

Kournioti, Chryssanthi ^{[15
]}

Yuan, Chen ^{[4
,5
]}

Zheng, Hui ^{[8
]}

Hollis, Bruce W. ^{[16
]}

Fuchs, Charles S. ^{[17
]}

Ng, Kimmie ^{[4
,5
]}

Meyerhardt, Jeffrey A. ^{[4
,5
]}

机构：

[1] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA

[2] New Orleans Sch Med, LSU Hlth Sci Ctr, New Orleans, LA 70012 USA

[3] Louisiana State Univ, Hlth Sci Ctr, Stanley S Scott Canc Ctr, New Orleans, LA 70012 USA

[4] Dana Farber Canc Inst, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Northwestern Univ, Div Hematol Oncol, Dept Med, Chicago, IL 60611 USA

[7] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] St Lukes Mt States Tumor Inst, Boise, ID 83712 USA

[10] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA

[11] Dana Farber Milford Reg Med Ctr, Milford, MA 01757 USA

[12] New Hampshire Oncol Hematol, Hookset, NH 03106 USA

[13] Dana Farber South Shore Hosp, South Weymouth, MA 02190 USA

[14] New England Canc Specialists, Scarborough, ME 04074 USA

[15] Newton Wellesley Hosp, Newton, MA 02462 USA

[16] Med Univ South Carolina, Dept Med, Dept Pediat, Charleston, SC 29425 USA

[17] Yale Canc Ctr, New Haven, CT 06510 USA

来源：

CANCERS | 2020年 / 12卷 / 11期

基金：

美国国家卫生研究院;

关键词：

adipose tissue; colorectal neoplasms; cholecalciferol; mediation; prognosis; randomized; skeletal muscle; ADIPOSE-TISSUE VOLUMES; SKELETAL-MUSCLE; METAANALYSIS; MORTALITY; STRENGTH; SURVIVAL; RECEPTOR; MODELS; MASS;

D O I：

10.3390/cancers12113451

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. It is unknown if high-dose vitamin D-3 impacts skeletal muscle and adipose tissue, as compared with standard-dose vitamin D-3, in patients with advanced or metastatic colorectal cancer. In this exploratory analysis of a phase II randomized trial, high-dose vitamin D-3 did not lead to changes of body weight, body mass index, muscle area, muscle attenuation, visceral adipose tissue area, or subcutaneous adipose tissue area, as compared with standard-dose vitamin D-3. High-dose vitamin D-3 did not change body composition in patients receiving chemotherapy for advanced or metastatic colorectal cancer. Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D-3 (4000 IU) or standard-dose (400 IU) vitamin D-3. Body composition was measured with abdominal computed tomography at enrollment (baseline) and after cycle 8 of chemotherapy (16 weeks). As compared with standard-dose vitamin D-3, high-dose vitamin D-3 did not significantly change body weight [-0.7 kg; (95% CI: -3.5, 2.0)], body mass index [-0.2 kg/m(2); (95% CI: -1.2, 0.7)], muscle area [-1.7 cm(2); (95% CI: -9.6, 6.3)], muscle attenuation [-0.4 HU; (95% CI: -4.2, 3.2)], visceral adipose tissue area [-7.5 cm(2); (95% CI: -24.5, 9.6)], or subcutaneous adipose tissue area [-8.3 cm(2); (95% CI: -35.5, 18.9)] over the first 8 cycles of chemotherapy. Among patients with advanced or metastatic colorectal cancer, the addition of high-dose vitamin D-3, vs standard-dose vitamin D-3, to standard chemotherapy did not result in any changes in body composition.

引用

页码：1 / 13

页数：13

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