Phoneutria nigriventer venom:: A cocktail of toxins that affect ion channels

被引：124
|
作者：
Gomez, MV
Kalapothakis, E
Guatimosim, C
Prado, MAM
机构：
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Morfol, Belo Horizonte, MG, Brazil
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2002年 / 22卷 / 5-6期
关键词：
Phoneutria nigriventer; toxins; ion channels; calcium channels; sodium channels; glutamate transport;
D O I：
10.1023/A:1021836403433
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
1. We review the pharmacological actions of toxins present in the venom of the aggressive spider Phoneutria nigriventer. 2. This venom is rich in toxins that affect ion channels and neurotransmitter release. Voltage-gated sodium, calcium, and potassium channels have been described as the main targets of these toxins. 3. In addition to these classical actions Phoneutria toxins have also been shown to affect glutamate transporter. 4. It is expected that molecular genetics in addition to biochemical, biophysical and pharmacological approaches will help to further define Phoneutria toxins and their mechanisms of action in the near future.
引用
收藏
页码：579 / 588
页数：10
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