Steroidal alkaloids and their glycosides from the bulbs of Fritillaria unibracteata

被引：6
|
作者：
Wang, Shu-Hui [1 ]
Liang, Hong [1 ]
Wang, Yu-Qi [1 ]
Tse, Wai-Gaun Kathy [2 ]
Dong, Hui-Wen [1 ]
Yang, Tie-Chui [2 ]
Zhang, Yun-Hu [1 ]
Zeng, Ke-Wu [1 ]
Tu, Peng-Fei [1 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Nin Jiom Med Manufactory HK Ltd, Hong Kong 999077, Peoples R China
来源：
STEROIDS | 2022年 / 181卷
关键词：
Fritillaria unibracteata; Steroidal alkaloid glycoside; Chemical hydrolysis; X-ray; EXPECTORANT;
D O I：
10.1016/j.steroids.2022.108977
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven undescribed steroidal alkaloids, including two jervine-type steroidal alkaloids, fritiunibras A-B (1-2), and five cevanine-type steroidal alkaloid glycosides, fritiunibras C-G (3-7), along with six known cevanine-type steroidal alkaloids and their glycosides (8-13) were isolated from the bulbs of Fritillaria unibracteata Hsiao et K. C. Hsia. Their structures were determined by interpretation of comprehensive spectroscopic and single-crystal X-ray diffraction analysis. The absolute configurations of sugar moieties were determined by HPLC analysis and compared with standards after hydrolysis and derivatization. Furthermore, their inhibitory effects on NO production and cytotoxic activities were evaluated.
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页数：9
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