Treatment with Erlotinib after Gefitinib Induced Hepatotoxicity: Literature Review and Case Report

被引：4

作者：

Durand, Marjorie ^{[1
]}

Logerot, Sophie ^{[1
]}

Fonrose, Xavier ^{[2
]}

Schir, Edith ^{[1
]}

机构：

[1] CHU Grenoble, Ctr Reg Pharmacovigilance Grenoble, F-38043 Grenoble 9, France

[2] CHU Grenoble, Inst Biol & Pathol, Lab Pharmacol & Toxicol, F-38043 Grenoble 9, France

来源：

THERAPIE | 2014年 / 69卷 / 02期

关键词：

non-small-cell lung carcinoma; gefinitib; erlotinib; molecular inhibitors of EGFR tyrosine kinase activity; hepatotoxicity; CELL LUNG-CANCER; DRUG-INTERACTIONS; METABOLISM; INHIBITOR; HEPATITIS; ZD1839;

D O I：

10.2515/therapie/2014017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gefitinib and erlotinib are selective epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor. They are approved for the treatment of adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating mutations of EGFR-TK. We report the case of a hepatitis cytolytic during gefitinib treatment with a positive rechallenge. A relay by erlotinib has been initiated and doesn't give recurrence of hepatotoxicity. From a literature review and this observation, arguments have been provided to justify erlotinib as a safe and well-tolered alternative for patients who have to stop gefitinib after a severe hepatotoxicity.

引用

页码：163 / 168

页数：6

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