Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes
被引:57
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作者:
Katsuda, Takeshi
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Natl Canc Ctr, Div Mol & Cellular Med, Tokyo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Katsuda, Takeshi
[1
]
Matsuzaki, Juntaro
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Natl Canc Ctr, Div Mol & Cellular Med, Tokyo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Matsuzaki, Juntaro
[1
]
Yamaguchi, Tomoko
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机构:
Natl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Keio Univ, Div Pharmacotherapeut, Fac Pharm, Tokyo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Yamaguchi, Tomoko
[1
,2
]
Yamada, Yasuhiro
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机构:
Nihon Pharmaceut Univ, Dept Clin Pharmaceut, Saitama, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Yamada, Yasuhiro
[3
]
Prieto-Vila, Marta
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机构:
Natl Canc Ctr, Div Mol & Cellular Med, Tokyo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Prieto-Vila, Marta
[1
]
Hosaka, Kazunori
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Natl Canc Ctr, Div Mol & Cellular Med, Tokyo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Hosaka, Kazunori
[1
]
Takeuchi, Atsuko
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机构:
Kobe Pharmaceut Univ, Div Analyt Lab, Kobe, Hyogo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Takeuchi, Atsuko
[4
]
Saito, Yoshimasa
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机构:
Keio Univ, Div Pharmacotherapeut, Fac Pharm, Tokyo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Saito, Yoshimasa
[2
]
Ochiya, Takahiro
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Natl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Tokyo Med Univ, Inst Med Sci, Tokyo, JapanNatl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
Ochiya, Takahiro
[1
,5
]
机构:
[1] Natl Canc Ctr, Div Mol & Cellular Med, Tokyo, Japan
[2] Keio Univ, Div Pharmacotherapeut, Fac Pharm, Tokyo, Japan
[3] Nihon Pharmaceut Univ, Dept Clin Pharmaceut, Saitama, Japan
[4] Kobe Pharmaceut Univ, Div Analyt Lab, Kobe, Hyogo, Japan
Hepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availability is limited due to a donor shortage. Thus, a novel cell source must be developed. We recently reported that mature rodent hepatocytes can be reprogrammed into progenitor-like cells with a repopulative capacity using small molecule inhibitors. Here, we demonstrate that hepatic progenitor cells can be obtained from human infant hepatocytes using the same strategy. These cells, named human chemically induced liver progenitors (hCLiPs), had a significant repopulative capacity in injured mouse livers following transplantation. hCLiPs redifferentiated into mature hepatocytes in vitro upon treatment with hepatic maturation-inducing factors. These redifferentiated cells exhibited cytochrome P450 (CYP) enzymatic activities in response to CYP-inducing molecules and these activities were comparable with those in primary human hepatocytes. These findings will facilitate liver cell transplantation therapy and drug discovery studies.
机构:
Capital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Tolerance Induct & Organ Protect T, 95 Yong An Rd, Beijing 100050, Peoples R China
Beijing Clin Res Inst, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Tolerance Induct & Organ Protect T, 95 Yong An Rd, Beijing 100050, Peoples R China
Liu, Kai
Li, Li
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机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Natl Clin Res Ctr Digest Dis, Beijing 100069, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Tolerance Induct & Organ Protect T, 95 Yong An Rd, Beijing 100050, Peoples R China
Li, Li
He, Yu
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机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Natl Clin Res Ctr Digest Dis, Beijing 100069, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Tolerance Induct & Organ Protect T, 95 Yong An Rd, Beijing 100050, Peoples R China
He, Yu
Zhang, Song
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机构:
Beijing Clin Res Inst, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Tolerance Induct & Organ Protect T, 95 Yong An Rd, Beijing 100050, Peoples R China
Zhang, Song
You, Hong
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机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Natl Clin Res Ctr Digest Dis, Beijing 100069, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Tolerance Induct & Organ Protect T, 95 Yong An Rd, Beijing 100050, Peoples R China
You, Hong
Wang, Ping
论文数: 0引用数: 0
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机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Natl Clin Res Ctr Digest Dis, Beijing 100069, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Tolerance Induct & Organ Protect T, 95 Yong An Rd, Beijing 100050, Peoples R China
机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Yang, Ai-Ting
Wang, Ping
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Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Wang, Ping
Tong, Xiao-Fei
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Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Tong, Xiao-Fei
Cong, Min
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Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Cong, Min
Liu, Tian-Hui
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Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Liu, Tian-Hui
Cong, Rui
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Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Cong, Rui
Wu, Peng
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机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Wu, Peng
Jia, Ji-Dong
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Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Jia, Ji-Dong
Wang, Bao-En
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机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
Wang, Bao-En
You, Hong
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机构:
Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
机构:
Yonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South KoreaYonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South Korea
Yoon, Yongdae
Gong, Seong Chan
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机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 26426, South KoreaYonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South Korea
Gong, Seong Chan
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机构:
Kim, Moon Young
Baik, Soon Koo
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机构:
Yonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South Korea
Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju 26426, South KoreaYonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South Korea
Baik, Soon Koo
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机构:
Hong, Ju-Eun
Rhee, Ki-Jong
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Yonsei Univ, Coll Software & Digital Healthcare Convergence, Dept Biomed Lab Sci, Mirae Campus, Wonju 26493, South KoreaYonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South Korea
Rhee, Ki-Jong
Ryu, Hoon
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机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 26426, South KoreaYonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South Korea
Ryu, Hoon
Eom, Young Woo
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机构:
Yonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South KoreaYonsei Univ, Wonju Coll Med, Regenerat Med Res Ctr, Wonju 26426, South Korea
机构:
Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Univ Geneva, Fac Med, Dept Pathol & Immunol, Pediat Surg Lab, Geneva, Switzerland
Schepens Eye Res Inst, Grousbeck Gene Therapy Ctr, Boston, MA USA
Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA
Harvard Med Sch, Ocular Genom Inst, Dept Ophthalmol, Boston, MA 02115 USAEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Unzu, Carmen
Planet, Evarist
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机构:
Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, SwitzerlandEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Planet, Evarist
Brandenberg, Nathalie
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Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, SwitzerlandEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Brandenberg, Nathalie
Fusil, Floriane
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机构:
Univ Claude Bernard Lyon 1, CIRI Int Ctr Infectiol Res, Team EVIR, CNRS,UMR5308,Ecole Normale Super Lyon,INSERM,U111, Lyon, FranceEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Fusil, Floriane
Cassano, Marco
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Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, SwitzerlandEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Cassano, Marco
Perez-Vargas, Jimena
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机构:
Univ Claude Bernard Lyon 1, CIRI Int Ctr Infectiol Res, Team EVIR, CNRS,UMR5308,Ecole Normale Super Lyon,INSERM,U111, Lyon, FranceEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Perez-Vargas, Jimena
Friedli, Marc
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Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, SwitzerlandEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Friedli, Marc
Cosset, Francois-Loic
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机构:
Univ Claude Bernard Lyon 1, CIRI Int Ctr Infectiol Res, Team EVIR, CNRS,UMR5308,Ecole Normale Super Lyon,INSERM,U111, Lyon, FranceEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
Cosset, Francois-Loic
Lutolf, Matthias P.
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Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, SwitzerlandEcole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland