Asymmetric synthesis of functionalized carbocycles and heterocycles

被引：0
|
作者：
Hanessian, S [1 ]
Griffin, AM [1 ]
Cantin, LD [1 ]
机构：
[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada
来源：
CHIRALITY | 2000年 / 12卷 / 5-6期
关键词：
conjugate addition; chiral allyl phosphonamide anions;
D O I：
10.1002/(SICI)1520-636X(2000)12:5/6<342::AID-CHIR7>3.0.CO;2-Y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Anions of 1-halo-4-hexenyl phosphonamides derived from chiral, enantiopure C-2 symmetrical 1,2-amino cyclohexane react at the gamma-position in conjugate addition reactions with alpha,beta-unsaturated carbonyl compounds such as cyclopentenone, 4-(H)-furanone, pyrroline-2-one, and cinnamates to give functionalized adducts. Addition to imines is also possible. The adducts can be transformed into enantiopure or enriched carbocyclic and heterocyclic compounds bearing useable functionality. (C) 2000 Wiley-Liss, Inc.
引用
收藏
页码：342 / 345
页数：4
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