Calcium imaging of sleep-wake related neuronal activity in the dorsal pons

被引：84
|
作者：
Cox, Julia [1 ,2 ]
Pinto, Lucas [1 ,2 ]
Dan, Yang [1 ]
机构：
[1] Univ Calif Berkeley, Howard Hughes Med Inst, Helen Wills Neurosci Inst, Div Neurobiol,Dept Mol & Cell Biol, 230 Li Ka Shing Ctr, Berkeley, CA 94720 USA
[2] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA
来源：
NATURE COMMUNICATIONS | 2016年 / 7卷
关键词：
PARADOXICAL REM SLEEP; PONTOMESENCEPHALIC TEGMENTUM; PONTINE TEGMENTUM; WAKING CYCLE; BRAIN; RAT; WAKEFULNESS; INDUCTION; MICE; MICROINJECTION;
D O I：
10.1038/ncomms10763
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.
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页数：7
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