Transgenic and Infectious Animal Models of HIV-Associated Nephropathy

被引：37

作者：

Rosenstiel, Paul ^{[1
]}

Gharavi, Ali ^{[2
]}

D'Agati, Vivette ^{[3
]}

Klotman, Paul ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

[2] Columbia Coll Phys & Surg, Dept Med, New York, NY USA

[3] Columbia Coll Phys & Surg, Dept Pathol, New York, NY USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 20卷 / 11期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; AIDS-LIKE DISEASE; RENAL-DISEASE; CELL-CYCLE; SEGMENTAL GLOMERULOSCLEROSIS; GENE-EXPRESSION; IN-VIVO; MICE; NEF; PODOCYTES;

D O I：

10.1681/ASN.2008121230

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Transgenic and infectious models of HIVAN faithfully recapitulate the human disease and are important tools in advancing our understanding of disease pathogenesis, genetic susceptibility, and therapeutic intervention beyond the inhibition of viral replication. This review discusses the available transgenic murine models and infectious models of HIVAN in mice, rats, nonhuman primates, and felines. Particular emphasis is given to cell type-specific HIV expression as well as partial HIV genome expression used to map HIV-1 Nef and Vpr as pathologic determinants.

引用

页码：2296 / 2304

页数：9

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