Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine

被引：33

作者：

Sorensen, Gunnar ^{[1
,2
]}

Wegener, Gregers ^{[3
]}

Hasselstrom, Jorgen ^{[3
]}

Hansen, Thomas V. O. ^{[4
]}

Wortwein, Gitta ^{[1
,2
]}

Fink-Jensen, Anders ^{[1
,2
]}

Woldbye, David P. D. ^{[1
,2
]}

机构：

[1] Rigshosp, Copenhagen Mental Hlth Ctr, Lab Neuropsychiat, Copenhagen, Denmark

[2] Univ Copenhagen, Dept Neurosci & Pharmacol, DK-1168 Copenhagen, Denmark

[3] Aarhus Univ Hosp, Ctr Psychiat Res, Risskov, Denmark

[4] Univ Copenhagen Hosp, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark

来源：

NEUROREPORT | 2009年 / 20卷 / 11期

关键词：

dopamine; microdialysis; neuropeptide Y; nucleus accumbens shell; reinforcement; ULTRASTRUCTURAL-LOCALIZATION; ETHANOL WITHDRAWAL; RECEPTORS; BRAIN; RELEASE; NPY;

D O I：

10.1097/WNR.0b013e32832d4848

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Increases in extracellular dopamine in the shell region of the nucleus accumbens are centrally involved in mediating reinforcement of addictive drugs. Neuropeptide Y (NPY) and its receptors are present in the nucleus accumbens and have been implicated in addiction mechanisms. This study further explored the potential role of NPY in addiction mechanisms using microdialysis to measure extracellular dopamine in vivo after infusion of NPY directly into the accumbal shell region of adult rats. NPY was found to dose-dependently increase extracellular dopamine levels, indicating that NPY could play an important role in drug reinforcement by modulating accumbal dopamine levels. NeuroReport 20:1023-1026 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：1023 / 1026

页数：4

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