Highly diastereo- and enantioselective Mukaiyama aldol reactions catalyzed by hydrogen bonding

被引：78
|
作者：
McGilvra, Jeff D. [1 ]
Unni, Aditya K. [1 ]
Modi, Kriti [1 ]
Rawal, Viresh H. [1 ]
机构：
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 37期
关键词：
asymmetric catalysis; enantioselectivity; hydrogen bonds; Mukaiyama aldol; organocatalysis;
D O I：
10.1002/anie.200601638
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Enzyme lite: Like a minimalist enzyme, a simple chiral alcohol of the taddol family, 1, catalyzes Mukaiyama aldol reactions between silyl enolates of amides and aldehydes to afford products with high diastereo- and enantioselectivities (see scheme; TBS = tert-butyldimethylsilyl). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6130 / 6133
页数：4
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