Optineurin Functions for Optimal Immunity

被引：21
|
作者：
Slowicka, Karolina [1 ,2 ]
van Loo, Geert [1 ,2 ]
机构：
[1] VIB Ctr Inflammat Res, Unit Cellular & Mol Pathophysiol, Ghent, Belgium
[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
关键词：
optineurin; inflammation; immunity; mitophagy/autophagy; nuclear factor-kappa B; ubiquitin; TANK-binding kinase 1; NF-KAPPA-B; AMYOTROPHIC-LATERAL-SCLEROSIS; OPEN-ANGLE GLAUCOMA; PAGETS-DISEASE; SELECTIVE AUTOPHAGY; CYTOKINE SECRETION; UBIQUITIN CHAINS; INTERFERON-BETA; CROHNS-DISEASE; GENETIC RISK;
D O I：
10.3389/fimmu.2018.00769
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor. Since then, OPTN has been identified as a ubiquitin-binding protein involved in many signaling pathways and cellular processes, and mutations in the OPTN gene have been associated with glaucoma, Paget's disease of bone and neurodegenerative pathologies. Its role in autophagy, however, has attracted most attention in recent years and may explain (some of) the mechanisms behind the disease-associated mutations of OPTN. In this brief review, we focus on the role of OPTN in inflammation and immunity and describe how this may translate to its involvement in human disease.
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页数：6
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