Human Th17 cells: Are they different from murine Th17 cells?

被引：50
|
作者：
Annunziato, Francesco [1 ]
Cosmi, Lorenzo [1 ]
Liotta, Francesco [1 ]
Maggi, Enrico [1 ]
Romagnani, Sergio [1 ]
机构：
[1] Univ Florence, Dept Internal Med, Ctr Excellence Res Transfer Res & High Educ Dev N, I-50134 Florence, Italy
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 03期
关键词：
Autoimmunity; Cytokines; Immune responses; NKT cells; Th cells; GROWTH-FACTOR-BETA; IL-17-PRODUCING T-CELLS; HUMAN T(H)17 CELLS; HUMAN T-H-17 CELLS; TGF-BETA; HUMAN NKR-P1A; NKT CELLS; IL-21; PATHWAYS; REQUIRES;
D O I：
10.1002/eji.200839050
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type 17 Th (Th17) cells have been identified as a distinct population of CD4(+) effector T cells different from Th1 and Th2 ceUs. While the pre-eminent cytokine of Th17 cells is IFN-gamma and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.
引用
收藏
页码：637 / 640
页数：4
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