Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study

被引：25

作者：

Kerr, William J. ^{[1
]}

Mudd, Richard J. ^{[1
]}

Owens, Philippa K. ^{[1
]}

Reid, Marc ^{[1
]}

Brown, Jack A. ^{[2
]}

Campos, Sebastien ^{[2
]}

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland

[2] GlaxoSmithKline R&D, Med Res Ctr, Stevenage, Herts, England

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2016年 / 59卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

ortho-hydrogen isotope exchange; N-heterocyclic carbene; deuteration; iridium; C-H ACTIVATION; DEUTERATION; CATALYSTS;

D O I：

10.1002/jlcr.3427

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein, we present a range of substrates that undergo hydrogen isotope exchange with an iridium(I) N-heterocyclic carbene/phosphine complex bearing the less coordinating tetrakis[3,5-bis(trifluoromethyl)phenyl] borate counterion and compare these with labelling using the equivalent, more established hexafluorophosphate complex. The changes in reactivity and selectivity of these complexes in a series of solvents are examined. Copyright (C) 2016 John Wiley & Sons, Ltd.

引用

页码：601 / 603

页数：3

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