"One-Pot" Synthesis of Well-Defined Functional Copolymer and Its Application as Tumor-Targeting Nanocarrier in Drug Delivery

被引:1
|
作者
Wang, Chenhong [1 ]
Qiao, Lei [1 ]
Yan, Husheng [2 ,3 ,4 ]
Liu, Keliang [1 ]
机构
[1] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
[2] Nankai Univ, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China
[3] Nankai Univ, Inst Polymer Chem, Tianjin 300071, Peoples R China
[4] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
基金
中国国家自然科学基金;
关键词
drug delivery systems; magnetism and magnetic properties; nanoparticles; nanowires and nanocrystals; radical polymerization; TRANSFER RADICAL POLYMERIZATION; IRON-OXIDE NANOPARTICLES; FOLATE-RECEPTOR; CLICK CHEMISTRY; TERMINAL ALKYNES; IMAGING AGENTS; IN-VITRO; POLYMERS; ACRYLATE; AZIDES;
D O I
10.1002/app.40405
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A one-pot synthesis is developed for PEG(600)-b-poly(glycerol monoacrylate) (PEG(600)-b-PGA), by which folate and superparamagnetic iron oxide nanoparticles (SPIONs) are assembled to form folic acid-conjugated magnetic nanoparticles (FA-MNPs) as a tumor targeting system. The synthesis consists of a click reaction and atom transfer radical polymerization (ATRP) to obtain the well-defined furan-protected maleimido-terminated PEG(600)-b-poly(solketal acrylate) (PEG(600)-b-PSA) copolymer. After deprotection, the key copolymer N-maleimido-terminated PEG(600)-b-PGA is successfully conjugated with thiol derivatives of folate and FITC, respectively. FA-MNPs are developed by assembling of the resulting polymer FA-PEG(600)-b-PGA with SPIONs, and characterized for their size, surface charge, and superparamagnetic properties. To investigate the cellular uptake of the nanoparticles by Hela cells and phi 2 cells using fluoresce technique, FA-FITC-MNPs are also obtained by assembling of FA-PEG(600)-b-PGA, FITC-PEG(600)-b-PGA with SPIONs. Qualitative and quantitative determinations of FA-FITC-MNPs show that the particles specifically internalized to Hela cells. No significant cytotoxicity is observed for these two kinds of cell lines. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40405.
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页数:10
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