Quantitative structural rearrangement of HIV-1 reverse transcriptase on binding to non-nucleoside inhibitors

被引：8
|
作者：
Lawtrakul, L
Beyer, A
Hannongbua, S
Wolschann, P
机构：
[1] Thammasat Univ, SIIT, Dept Common & Grad Studies, Pathum Thani 12121, Thailand
[2] Res Inst Mol Pathol, A-1030 Vienna, Austria
[3] Kasetsart Univ, Fac Sci, Dept Chem, Bangkok 10900, Thailand
[4] Inst Theoret Chem & Struct Biol, A-1090 Vienna, Austria
来源：
MONATSHEFTE FUR CHEMIE | 2004年 / 135卷 / 08期
关键词：
HIV-1 reverse transcriptase; non-nucleoside inhibitors; protein-ligand interactions;
D O I：
10.1007/s00706-004-0172-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The crystal structures of HIV-1 reverse transcriptase (RT) and some of its inhibitor complexes have been compared quantitatively with respect to backbone and side chain dihedral angles. Furthermore distances between inhibitor molecules and surrounding amino acids have been analyzed in detail. The calculation of the conformation for all structures allows us to determine quantitative structural changes of HIV-1 RT on binding to NNIs or to RNA/DNA.
引用
收藏
页码：1033 / 1046
页数：14
相关论文
共 50 条
  • [11] HIV-1 reverse transcriptase resistance to non-nucleoside inhibitors.
    Spence, RA
    Johnson, KA
    BIOPHYSICAL JOURNAL, 1996, 70 (02) : MP356 - MP356
  • [12] Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
    Famiglini, Valeria
    Silvestri, Romano
    MOLECULES, 2016, 21 (02):
  • [13] Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1
    Chan, JH
    Freeman, GA
    Tidwell, JH
    Romines, KR
    Schaller, LT
    Cowan, JR
    Gonzales, SS
    Lowell, GS
    Andrews, CW
    Reynolds, DJ
    St Clair, M
    Hazen, RJ
    Ferris, RG
    Creech, KL
    Roberts, GB
    Short, SA
    Weaver, K
    Koszalka, GW
    Boone, LR
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (05) : 1175 - 1182
  • [14] Halolactones are potent HIV-1 non-nucleoside reverse transcriptase inhibitors
    Han, Xin
    Wu, Haoming
    Dong, Chune
    Tien, Po
    Xie, Wei
    Wu, Shuwen
    Zhou, Hai-Bing
    RSC ADVANCES, 2015, 5 (13): : 10005 - 10013
  • [15] Structural aspects of non-nucleoside HIV-1 reverse transcriptase inhibition
    Beyer, Anton
    Lawtrakul, Luckhana
    Pungpo, Pornpan
    Wolschann, Peter
    CURRENT COMPUTER-AIDED DRUG DESIGN, 2007, 3 (02) : 87 - 100
  • [16] NMR characterization of HIV-1 reverse transcriptase binding to various non-nucleoside reverse transcriptase inhibitors with different activities
    Thammaporn, Ratsupa
    Yagi-Utsumi, Maho
    Yamaguchi, Takumi
    Boonsri, Pornthip
    Saparpakorn, Patchreenart
    Choowongkomon, Kiattawee
    Techasakul, Supanna
    Kato, Koichi
    Hannongbua, Supa
    SCIENTIFIC REPORTS, 2015, 5
  • [17] NMR characterization of HIV-1 reverse transcriptase binding to various non-nucleoside reverse transcriptase inhibitors with different activities
    Ratsupa Thammaporn
    Maho Yagi-Utsumi
    Takumi Yamaguchi
    Pornthip Boonsri
    Patchreenart Saparpakorn
    Kiattawee Choowongkomon
    Supanna Techasakul
    Koichi Kato
    Supa Hannongbua
    Scientific Reports, 5
  • [18] HIV-1 non-nucleoside reverse transcriptase inhibitor
    Lloyd, AW
    DRUG DISCOVERY TODAY, 1998, 3 (08) : 387 - 387
  • [19] Mass Spectrometric Characterization of HIV-1 Reverse Transcriptase Interactions with Non-nucleoside Reverse Transcriptase Inhibitors
    Thammaporn, Ratsupa
    Ishii, Kentaro
    Yagi-Utsumi, Maho
    Uchiyama, Susumu
    Hannongbua, Supa
    Kato, Koichi
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2016, 39 (03) : 450 - 454
  • [20] Docking study of non-nucleoside inhibitors of HIV-1 reverse transcriptase.
    Zhou, ZG
    Madrid, M
    Madura, J
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : U465 - U465
12345