Quantitative structural rearrangement of HIV-1 reverse transcriptase on binding to non-nucleoside inhibitors

被引：8
|
作者：
Lawtrakul, L
Beyer, A
Hannongbua, S
Wolschann, P
机构：
[1] Thammasat Univ, SIIT, Dept Common & Grad Studies, Pathum Thani 12121, Thailand
[2] Res Inst Mol Pathol, A-1030 Vienna, Austria
[3] Kasetsart Univ, Fac Sci, Dept Chem, Bangkok 10900, Thailand
[4] Inst Theoret Chem & Struct Biol, A-1090 Vienna, Austria
来源：
MONATSHEFTE FUR CHEMIE | 2004年 / 135卷 / 08期
关键词：
HIV-1 reverse transcriptase; non-nucleoside inhibitors; protein-ligand interactions;
D O I：
10.1007/s00706-004-0172-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The crystal structures of HIV-1 reverse transcriptase (RT) and some of its inhibitor complexes have been compared quantitatively with respect to backbone and side chain dihedral angles. Furthermore distances between inhibitor molecules and surrounding amino acids have been analyzed in detail. The calculation of the conformation for all structures allows us to determine quantitative structural changes of HIV-1 RT on binding to NNIs or to RNA/DNA.
引用
收藏
页码：1033 / 1046
页数：14
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