Plasma Biomarkers: Potent Screeners of Alzheimer's Disease

被引:13
|
作者
Naveed, Muhammad [1 ]
Mubeen, Shamsa [2 ]
Khan, Abeer [3 ]
Ibrahim, Sehrish [3 ]
Meer, Bisma [3 ]
机构
[1] Univ Cent Punjab, Dept Biotechnol, Fac Life Sci, Lahore 54000, Pakistan
[2] Univ Gujrat, Dept Biochem & Mol Biol, Gujrat, Pakistan
[3] Univ Gujrat, Dept Biotechnol, Gujrat, Pakistan
来源
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2019年 / 34卷 / 05期
关键词
Alzheimer's disease; brain cell death; plasma biomarkers; diagnosis; MILD COGNITIVE IMPAIRMENT; APOLIPOPROTEIN-A-I; CEREBROSPINAL-FLUID; PROTEOMIC IDENTIFICATION; CLUSTERIN CONCENTRATION; FETUIN-A; PROTEIN; DEMENTIA; BRAIN; PROGRESSION;
D O I
10.1177/1533317519848239
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Alzheimer's disease (AD), a neurological disorder, is as a complex chronic disease of brain cell death that usher to cognitive decline and loss of memory. Its prevalence differs according to risk factors associated with it and necropsy performs vital role in its definite diagnosis. The stages of AD vary from preclinical to severe that proceeds to death of patient with no availability of treatment. Biomarker may be a biochemical change that can be recognized by different emerging technologies such as proteomics and metabolomics. Plasma biomarkers, 5-protein classifiers, are readily being used for the diagnosis of AD and can also predict its progression with a great accuracy, specificity, and sensitivity. In this review, upregulation or downregulation of few plasma proteins in patients with AD has also been discussed, when juxtaposed with control, and thus serves as potent biomarker in the diagnosis of AD.
引用
收藏
页码:290 / 301
页数:12
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