What next in cervical cancer screening?

被引:0
|
作者
Sehnal, B. [1 ]
Slama, J. [2 ]
机构
[1] Gynekol Porodnicka Klin, Onkogynekol Ctr, Nemocn Bulovce LF UK 1, Prague, Czech Republic
[2] Gynekol Porodnicka Klin Vseobecne, Onkogynekol Ctr, Fak Nemocnice LF UK 1, Prague, Czech Republic
来源
CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY | 2020年 / 85卷 / 04期
关键词
cervical cancer; screening; molecular methods; HPV test; p16/Ki67; methylation; E6/E7; mRNA; CYTOLOGY; WOMEN; RISK; US;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Introduction: The main aim of organized national cervical cancer screening programs is to decrease incidence and mortality of this malignancy. A total of 770 cases of cervical cancer and 354 deaths from the disease were noticed in the Czech Republic in 2017 which means the incidence 14,5 new cases per 100 000 women. The Czech national cervical cancer screening program is based on cytology (Pap smear) testing in asymptomatic women once a year. Objective: To provide an overview of new possibilities and potential tools in cervical cancer screening worldwide and in the Czech Republic. Setting: Gynecologic Oncology Center, Department of Gynecology and Obstetrics, Hospital Na Bulovce and 1st Medical School of Charles University, Prague; Gynecologic Oncology Center, Department of Gynecology and Obstetrics, General Faculty Hospital and 1st Medical School of Charles University, Prague. Methods: For this review, we have used the results of studies, review articles, and guidelines of national cervical cancer screening programs published in English. We summarize the current knowledge of molecular genetic methods being applied in the screening of cervical carcinoma. Conclusion: The knowledge that persistent human papillomavirus (HPV) infection is the main cause of cervical cancer has resulted in the development of new possibilities of cervical cancer screening worldwide. HPV testing use for cervical cancer screening is now a reality with a quite lot of countries. Nevertheless, HPV testing is mainly used in the stratification of patients with unclear results of a cytological (PAP smear) result in the Czech Republic. While there is a wide and growing consensus that HPV molecular testing is the most accurate and cost-effective method of primary screening, there is a comparative lack of consensus regarding the optimal stratification of patients with proven HPV infections. Biomarkers, such a p16/Ki67 dual immunostaining, a methylation of viral DNA, a detection of E6/E7 mRNA, and others have been proposed for triage of HPV positive women. New possibilities and approaches in strategy of cervical cancer screening are discussed.
引用
收藏
页码:236 / 243
页数:8
相关论文
共 50 条
  • [31] Cervical Cancer Screening: What's New? Updates for the Busy Clinician
    Zhang, Salina
    McNamara, Megan
    Batur, Pelin
    AMERICAN JOURNAL OF MEDICINE, 2018, 131 (06): : 702.e1 - 702.e5
  • [32] A Review on Cervical Cancer Screening in Transgender Men: What Are the Particularities of This Approach?
    Okano, Sergio Henrique Pires
    Daud, Mirella de Freitas
    Carneiro, Andria Karoliny Schneider
    Braga, Giordana Campos
    TRANSGENDER HEALTH, 2024,
  • [33] Section Editor's Notebook: Breast Cancer Screening-What Now, and What Next?
    Javitt, Marcia C.
    AMERICAN JOURNAL OF ROENTGENOLOGY, 2018, 210 (02) : 239 - 240
  • [34] What Promotes Cervical Cancer Screening Among Chamorro Women in California?
    Tanjasiri, Sora P.
    Mouttapa, Michele
    Sablan-Santos, Lola
    Quitugua, Lourdes F.
    JOURNAL OF CANCER EDUCATION, 2012, 27 (04) : 725 - 730
  • [35] Screening Colonoscopy - what comes next?
    Birkner, Berndt
    GASTROENTEROLOGE, 2007, 2 (04): : 294 - 294
  • [36] What next for preimplantation genetic screening?
    Harper, Joyce
    Sermon, Karen
    Geraedts, Joep
    Vesela, Katerina
    Harton, Gary
    Thornhill, Alan
    Pehlivan, Tugce
    Fiorentino, Francesco
    SenGupta, Sioban
    de Die-Smulders, Christine
    Magli, Cristina
    Moutou, Celine
    Wilton, Leeanda
    HUMAN REPRODUCTION, 2008, 23 (03) : 478 - 480
  • [37] Cervical Cancer Screening
    Voelker, Rebecca A.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2023, 330 (20): : 2030 - 2030
  • [38] SCREENING FOR CERVICAL CANCER
    WILSON, M
    CHAMBERLAIN, J
    COCHRANE, AL
    LANCET, 1971, 1 (7693): : 297 - +
  • [39] Cervical Cancer Screening
    Schorge, John O.
    CLINICAL OBSTETRICS AND GYNECOLOGY, 2013, 56 (01): : 1 - 2
  • [40] Cervical cancer screening
    不详
    LABMEDICINE, 2007, 38 (05): : 260 - +