Nanocrystalline titanium dioxide and magnesium oxide in vitro dermal absorption in human skin

被引：19
|
作者：
van der Merwe, Deon [1 ]
Tawde, Snehal
Pickrell, John A.
Erickson, Larry E. [1 ]
机构：
[1] Kansas State Univ, Ctr Hazardous Substance Res, Manhattan, KS 66506 USA
来源：
CUTANEOUS AND OCULAR TOXICOLOGY | 2009年 / 28卷 / 02期
关键词：
Dermal absorption; metal oxides; nanocrystalline; titanium dioxide; magnesium oxide; ZINC-OXIDE; PENETRATION; NANOPARTICLES; PERMEABILITY; FORMULATION;
D O I：
10.1080/15569520902914926
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The dermal absorption potential of a nanocrystalline magnesium oxide (MgO) and titanium dioxide (TiO2) mixture in dermatomed human skin was assessed in vitro using Bronaugh-type flow-through diffusion cells. Nanocrystalline material was applied to the skin surface at a dose rate of 50 mg/cm(2) as a dry powder, as a water suspension, and as a water/surfactant (sodium lauryl sulfate) suspension, for 8 hours. Dermal absorption of nanocrystalline MgO and TiO2 through human skin with intact, functional stratum corneum was not detectable under the conditions of this experiment.
引用
收藏
页码：78 / 82
页数：5
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