Structure-activity relationship studies of gymnocin-A

被引：20
|
作者：
Tsukano, Chihiro [1 ]
Sasaki, Makoto [1 ]
机构：
[1] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 38期
基金：
日本学术振兴会;
关键词：
D O I：
10.1016/j.tetlet.2006.07.081
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The structural elements required for cytotoxicity of gymnocin-A, a polycyclic ether isolated from the red tide-forming dinoflagellate, Karenia mikimotoi, were investigated by the total synthesis and evaluation of the structural analogues. The results of the structure-activity relationship studies indicated that the alpha,beta-unsaturated aldehyde functionality of the side chain as well as the molecular length were needed for exhibiting the cytotoxicity of gymnocin-A. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6803 / 6807
页数：5
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