Synthetic approaches to the 2012 new drugs

被引：38
|
作者：
Ding, Hong X. [1 ]
Leverett, Carolyn A. [2 ]
Kyne, Robert E., Jr. [2 ]
Liu, Kevin K. -C. [3 ]
Sakya, Subas M. [4 ]
Flick, Andrew C. [2 ]
O'Donnell, Christopher J. [2 ]
机构：
[1] PharmaPhase Co Ltd, Beijing 100193, Peoples R China
[2] Pfizer Worldwide Res & Dev, Groton Labs, Groton, CT 06340 USA
[3] Lilly China Res & Dev Ctr, Shanghai 201203, Peoples R China
[4] BioDuro Co Ltd, Shanghai 200131, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2014年 / 22卷 / 07期
关键词：
Synthesis; New drug molecules; New chemical entities; Medicine; Therapeutic agents; CHRONIC MYELOID-LEUKEMIA; ANTIINFLAMMATORY AGENT 3-FORMYLAMINO-7-METHYLSULFONYLAMINO-6-PHENOXY-4H-1-BENZOPYRAN-4-ONE; DIHYDROOROTATE DEHYDROGENASE; ANTITUMOR ALKALOIDS; PASIREOTIDE SOM230; INGENOL ESTERS; IN-VITRO; INHIBITOR; POTENT; DISCOVERY;
D O I：
10.1016/j.bmc.2014.02.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New drugs introduced to the market every year represent a privileged structure for a particular biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of twenty-six NCEs that were launched or approved worldwide in 2012 and two additional drugs which were launched at the end of 2011. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2005 / 2032
页数：28
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