Rapid fluorous Stille coupling reactions conducted under microwave irradiation

被引：105
|
作者：
Larhed, M
Hoshino, M
Hadida, S
Curran, DP
Hallberg, A
机构：
[1] UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15260
[2] UNIV UPPSALA,CTR BIOMED,DEPT ORGAN PHARMACEUT CHEM,S-75123 UPPSALA,SWEDEN
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 16期
关键词：
D O I：
10.1021/jo970362y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed fluorous Stille cross-coupling reactions with organic halides or triflates require only 90-120 s for completion when conducted under microwave irradiation. Comparable thermal reactions require about 1 day. Fourteen different coupling products were synthesized and isolated in good yields after three-phase extraction (FC-84, dichloromethane, water) and chromatography. The examples extend the scope of the fluorous Stille coupling with respect to both the tin and halide/triflate components. Applications in parallel synthesis are suggested.
引用
收藏
页码：5583 / 5587
页数：5
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