Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

被引：44

作者：

Horsburgh, Karen ^{[1
]}

Wardlaw, Joanna M. ^{[2
]}

van Agtmael, Tom ^{[3
]}

Allan, Stuart M. ^{[4
]}

Ashford, Mike L. J. ^{[5
]}

Bath, Philip M. ^{[6
]}

Brown, Rosalind ^{[7
]}

Berwick, Jason ^{[8
]}

Cader, M. Zameel ^{[9
]}

Carare, Roxana O. ^{[10
]}

Davis, John B. ^{[11
]}

Duncombe, Jessica ^{[1
]}

Farr, Tracy D. ^{[12
]}

Fowler, Jill H. ^{[1
]}

Goense, Jozien ^{[13
]}

Granata, Alessandra ^{[14
]}

Hall, Catherine N. ^{[15
]}

Hainsworth, Atticus H. ^{[16
]}

Harvey, Adam ^{[3
]}

Hawkes, Cheryl A. ^{[17
]}

Joutel, Anne ^{[18
]}

Kalaria, Rajesh N. ^{[19
]}

Kehoe, Patrick G. ^{[20
]}

Lawrence, Catherine B. ^{[4
]}

Lockhart, Andy ^{[21
]}

Love, Seth ^{[22
]}

Macleod, Malcolm R. ^{[7
]}

Macrae, I. Mhairi ^{[13
]}

Markus, Hugh S. ^{[14
]}

McCabe, Chris ^{[13
]}

McColl, Barry W. ^{[23
,24
]}

Meakin, Paul J. ^{[25
]}

Miller, Alyson ^{[3
]}

Nedergaard, Maiken ^{[26
,27
]}

O'Sullivan, Michael ^{[28
,29
]}

Quinn, Terry J. ^{[3
]}

Rajani, Rikesh ^{[18
]}

Saksida, Lisa M. ^{[30
]}

Smith, Colin ^{[7
]}

Smith, Kenneth J. ^{[31
]}

Touyz, Rhian M. ^{[3
]}

Trueman, Rebecca C. ^{[12
]}

Wang, Tao ^{[4
]}

Williams, Anna ^{[32
]}

Williams, Steven C. R. ^{[33
]}

Work, Lorraine M. ^{[3
]}

机构：

[1] Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland

[2] Univ Edinburgh, UK Dementia Res Inst, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[3] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland

[4] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England

[5] Univ Dundee, Sch Med, Dundee, Scotland

[6] Univ Nottingham, Div Clin Neurosci, Stroke Trials Unit, Nottingham, England

[7] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[8] Univ Sheffield, Dept Psychol, Sheffield, S Yorkshire, England

[9] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[10] Univ Southampton, Fac Med, Southampton, Hants, England

[11] Univ Oxford, Alzheimers Res UK Oxford Drug Discovery Inst, Oxford, England

[12] Univ Nottingham, Sch Life Sci, Nottingham, England

[13] Univ Glasgow, Inst Neurosci & Psychol, Glasgow, Lanark, Scotland

[14] Univ Cambridge, Dept Clin Neurosci, Cambridge, England

[15] Univ Sussex, Sch Psychol, Brighton, E Sussex, England

[16] St Georges Univ London, Mol & Clin Sci Res Inst, London, England

[17] Open Univ, Fac Sci Technol Engn & Math, Milton Keynes, Bucks, England

[18] Univ Paris Diderot Paris 7, INSERM, Genet & Pathogenesis Cerebrovasc Dis, Paris, France

[19] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England

[20] Univ Bristol, Bristol Med Sch, Bristol, Avon, England

[21] Heptares Therapeut, GSK, London, England

[22] Univ Bristol, Clin Neurosci, Bristol, Avon, England

[23] Univ Edinburgh, Roslin Inst, Edinburgh, Midlothian, Scotland

[24] Univ Edinburgh, R D SVS, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland

[25] Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland

[26] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

[27] Univ Copenhagens, Ctr Basic & Translat Neurosci, Copenhagen, Denmark

[28] Mater Ctr Neurosci, Brisbane, Qld, Australia

[29] Queensland Brain Inst, Brisbane, Qld, Australia

[30] Western Univ, Robarts Res Inst, London, ON, Canada

[31] UCL Inst Neurol, Dept Neuroinflammat, London, England

[32] Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh, Midlothian, Scotland

[33] Kings Coll London, Inst Psychiat, London, England

来源：

CLINICAL SCIENCE | 2018年 / 132卷 / 08期

关键词：

VASCULAR COGNITIVE IMPAIRMENT; TOUCHSCREEN OPERANT PLATFORM; BLOOD-BRAIN-BARRIER; CHRONIC CEREBRAL HYPOPERFUSION; WHITE-MATTER HYPERINTENSITIES; PLURIPOTENT STEM-CELLS; ALZHEIMERS-DISEASE; ENDOTHELIAL DYSFUNCTION; MOUSE MODEL; MULTIPLE-SCLEROSIS;

D O I：

10.1042/CS20171620

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

引用

页码：851 / 868

页数：18

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