Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease

被引：11
|
作者：
Brickman, Adam M. [1 ,2 ,3 ]
Manly, Jennifer J. [1 ,2 ,3 ]
Honig, Lawrence S. [1 ,2 ,3 ]
Sanchez, Danurys [1 ,2 ,3 ]
Reyes-Dumeyer, Dolly [1 ,2 ,3 ]
Lantigua, Rafael A. [1 ,4 ]
Vonsattel, Jean Paul [1 ,4 ,5 ]
Teich, Andrew F. [1 ,5 ]
Kang, Min Suk [1 ]
Dage, Jeffrey L. [6 ,7 ]
Mayeux, Richard [1 ,2 ,3 ]
机构：
[1] Columbia Univ, Vagelos Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA
[2] Columbia Univ, Vagelos Coll Phys & Surg, GH Sergievsky Ctr, New York, NY 10027 USA
[3] Columbia Univ, Vagelos Coll Phys & Surg, Dept Neurol, New York, NY USA
[4] New York Presbyterian Hosp, New York, NY USA
[5] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, New York, NY USA
[6] Columbia Univ, Vagelos Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY USA
[7] Indiana Univ, Sch Med, Stark Neurosci Res Inst, Indianapolis, IN USA
来源：
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2022年 / 9卷 / 05期
基金：
美国国家卫生研究院;
关键词：
DEMENTIA; TAU;
D O I：
10.1002/acn3.51529
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Blood-based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau-) based on Ptau 181 and 217 concentrations and as cognitively impaired (Sym) or unimpaired (Asym). The four groups, Ptau-/Asym, Ptau+/Asym, Ptau-/Sym, and Ptau+/Sym, differed by age, APOE-4 allele frequency, total tau, neurofilament light chain, and cortical thickness measured by MRI. Our results add to increasing evidence that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations.
引用
收藏
页码：756 / 761
页数：6
相关论文
共 50 条
  • [31] Plasma Biomarkers of Brain Atrophy in Alzheimer's Disease
    Thambisetty, Madhav
    Simmons, Andrew
    Hye, Abdul
    Campbell, James
    Westman, Eric
    Zhang, Yi
    Wahlund, Lars-Olof
    Kinsey, Anna
    Causevic, Mirsada
    Killick, Richard
    Kloszewska, Iwona
    Mecocci, Patrizia
    Soininen, Hilkka
    Tsolaki, Magda
    Vellas, Bruno
    Spenger, Christian
    Lovestone, Simon
    PLOS ONE, 2011, 6 (12):
  • [32] Plasma Biomarkers of Alzheimer's Disease in African Americans
    Deniz, Kaancan
    Ho, Charlotte C. G.
    Malphrus, Kimberly G.
    Reddy, Joseph S.
    Nguyen, Thuy
    Carnwath, Troy P.
    Crook, Julia E.
    Lucas, John A.
    Graff-Radford, Neill R.
    Carrasquillo, Minerva M.
    Ertekin-Taner, Nilufer
    JOURNAL OF ALZHEIMERS DISEASE, 2021, 79 (01) : 323 - 334
  • [33] Sleep deprivation and plasma biomarkers for Alzheimer's disease
    Olsson, Martin
    Arlig, Johan
    Hedner, Jan
    Blennow, Kaj
    Zetterberg, Henrik
    SLEEP MEDICINE, 2019, 57 : 92 - 93
  • [34] Assessment of the quality of brain regions and neuroimaging metrics as biomarkers of Alzheimer’s Disease
    Tânia Faria Vaz
    Filipa Lucena
    Joana Pé-Leve
    André Santos Ribeiro
    Luís Lacerda
    Nuno da Silva
    David Nutt
    John McGonigle
    Hugo Alexandre Ferreira
    EJNMMI Physics, 2 (Suppl 1)
  • [35] The Alzheimer's Disease Neuroimaging Initiative: Annual change in biomarkers and clinical outcomes
    Beckett, Laurel A.
    Harvey, Danielle J.
    Gamst, Anthony
    Donohue, Michael
    Kornak, John
    Zhang, Hao
    Kuo, Julie H.
    ALZHEIMERS & DEMENTIA, 2010, 6 (03) : 257 - 264
  • [36] Neuroimaging and Other Biomarkers for Alzheimer's Disease: The Changing Landscape of Early Detection
    Risacher, Shannon L.
    Saykin, Andrew J.
    ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9, 2013, 9 : 621 - 648
  • [37] Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers
    Chetelat, G.
    Fouquet, M.
    REVUE NEUROLOGIQUE, 2013, 169 (10) : 729 - 736
  • [38] Role of amyloid β1-42 and neuroimaging biomarkers in Alzheimer's disease
    Lista, Simone
    Emanuele, Enzo
    BIOMARKERS IN MEDICINE, 2011, 5 (04) : 411 - 413
  • [39] Transfer Learning for Alzheimer's Disease through Neuroimaging Biomarkers: A Systematic Review
    Agarwal, Deevyankar
    Marques, Goncalo
    de la Torre-Diez, Isabel
    Franco Martin, Manuel A.
    Garcia Zapirain, Begona
    Martin Rodriguez, Francisco
    SENSORS, 2021, 21 (21)
  • [40] Biomarkers of Alzheimer Disease in Plasma
    Irizarry M.C.
    NeuroRX, 2004, 1 (2): : 226 - 234
12345