Expeditious synthesis of 2-aryl substituted imidazolines and imidazoles

被引：14
|
作者：
Lauwagie, Sylvia [1 ]
Millet, Regis [1 ]
Pommery, Jean [1 ]
Depreux, Patrick [1 ]
Henichart, Jean-Pierre [1 ]
机构：
[1] Univ Lille 2, Inst Chim Pharmaceut Albert Lespagnol, F-59006 Lille, France
来源：
HETEROCYCLES | 2006年 / 68卷 / 06期
关键词：
D O I：
10.3987/COM-06-10708
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A versatile and efficient method for the synthesis of 2-aryl substituted imidazolines and imidazoles bearing a carboxylate group on C-4 is reported. Three different synthetic pathways were explored, compared and optimized. The selected procedure involves condensation of methyl 2,3-diaminopropionate with different imino ethers. The ring closure, monitored by LC-MS analysis, was facilitated by heating at reflux in ethanol leading to increase the rate of cyclization.
引用
收藏
页码：1149 / +
页数：15
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