Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes

被引：79
|
作者：
Paolino, Donatella [1 ,9 ]
Cosco, Donato [1 ,9 ]
Gaspari, Marco [2 ]
Celano, Marilena [1 ]
Wolfram, Joy [3 ,4 ]
Voce, Pasquale [5 ]
Puxeddu, Efisio [5 ]
Filetti, Sebastiano [6 ]
Celia, Christian [3 ,7 ,9 ]
Ferrari, Mauro [3 ,8 ]
Russo, Diego [1 ]
Fresta, Massimo [1 ,9 ]
机构：
[1] Univ Catanzaro Magna Graecia, Dept Hlth Sci, I-88100 Catanzaro, Italy
[2] Univ Catanzaro Magna Graecia, Dept Expt & Clin Med, I-88100 Catanzaro, Italy
[3] Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
[4] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[5] Univ Perugia, Dept Internal Med, I-06123 Perugia, Italy
[6] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, I-00161 Rome, Italy
[7] Univ Chieti Pescara G d Annunzio, Dept Pharm, I-66013 Chieti, Italy
[8] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA
[9] Univ Catanzaro Magna Graecia, IRC FSH Interreg Res Ctr Food Safety & Hlth, I-88100 Catanzaro, Italy
来源：
BIOMATERIALS | 2014年 / 35卷 / 25期
关键词：
Nanoliposomes; Nanoparticles; Targeting; Thyroid cancer; Thyroid gland; PEGYLATED UNILAMELLAR LIPOSOMES; VIVO ANTITUMOR-ACTIVITY; THYROTROPIN RECEPTOR; LOADED LIPOSOMES; PHARMACOKINETIC FEATURES; IODINE-METABOLISM; ANTICANCER DRUGS; GEMCITABINE; DELIVERY; EXPRESSION;
D O I：
10.1016/j.biomaterials.2014.04.088
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed. Here, we have developed a nanodelivery system that targets the thyroid gland. Nano-liposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy in vitro and in a tumor model of follicular thyroid carcinoma. This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy. (C) 2014 The Authors. Published by Elsevier Ltd.
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页码：7101 / 7109
页数：9
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