Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes

被引：80

作者：

Paolino, Donatella ^{[1
,9
]}

Cosco, Donato ^{[1
,9
]}

Gaspari, Marco ^{[2
]}

Celano, Marilena ^{[1
]}

Wolfram, Joy ^{[3
,4
]}

Voce, Pasquale ^{[5
]}

Puxeddu, Efisio ^{[5
]}

Filetti, Sebastiano ^{[6
]}

Celia, Christian ^{[3
,7
,9
]}

Ferrari, Mauro ^{[3
,8
]}

Russo, Diego ^{[1
]}

Fresta, Massimo ^{[1
,9
]}

机构：

[1] Univ Catanzaro Magna Graecia, Dept Hlth Sci, I-88100 Catanzaro, Italy

[2] Univ Catanzaro Magna Graecia, Dept Expt & Clin Med, I-88100 Catanzaro, Italy

[3] Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

[4] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[5] Univ Perugia, Dept Internal Med, I-06123 Perugia, Italy

[6] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, I-00161 Rome, Italy

[7] Univ Chieti Pescara G d Annunzio, Dept Pharm, I-66013 Chieti, Italy

[8] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA

[9] Univ Catanzaro Magna Graecia, IRC FSH Interreg Res Ctr Food Safety & Hlth, I-88100 Catanzaro, Italy

来源：

BIOMATERIALS | 2014年 / 35卷 / 25期

关键词：

Nanoliposomes; Nanoparticles; Targeting; Thyroid cancer; Thyroid gland; PEGYLATED UNILAMELLAR LIPOSOMES; VIVO ANTITUMOR-ACTIVITY; THYROTROPIN RECEPTOR; LOADED LIPOSOMES; PHARMACOKINETIC FEATURES; IODINE-METABOLISM; ANTICANCER DRUGS; GEMCITABINE; DELIVERY; EXPRESSION;

D O I：

10.1016/j.biomaterials.2014.04.088

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed. Here, we have developed a nanodelivery system that targets the thyroid gland. Nano-liposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy in vitro and in a tumor model of follicular thyroid carcinoma. This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy. (C) 2014 The Authors. Published by Elsevier Ltd.

引用

页码：7101 / 7109

页数：9

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