Living Donor Liver Transplantation for Hepatocellular Carcinoma within Milan Criteria in the Present Era

被引：0
|
作者：
Yoshizumi, Tomoharu [1 ]
Harimoto, Norifumi [1 ]
Itoh, Shinji [1 ]
Okabe, Hirohisa [1 ]
Kimura, Koichi [1 ]
Uchiyama, Hideaki [1 ]
Ikegami, Toru [1 ]
Ikeda, Tetsuo [1 ]
Maehara, Yoshihiko [1 ]
机构：
[1] Kyushu Univ, Dept Surg & Sci, Grad Sch Med Sci, Fukuoka 8128582, Japan
来源：
ANTICANCER RESEARCH | 2016年 / 36卷 / 01期
关键词：
Living donor liver transplantation; hepatocellular carcinoma; Milan; criteria; NLR; NEUTROPHIL-LYMPHOCYTE RATIO; CURATIVE RESECTION; TUMOR SIZE; RECURRENCE; IMPACT; GRAFT; SELECTION; SURVIVAL; RISK; HCV;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The aim of the present study was to clarify the outcome of living donor liver transplantation (LDLT) in patients with hepatocellular carcinoma (HCC) within Milan criteria. Patients and Methods: The study comprised of 197 adult patients. One hundred twenty-nine patients were within Milan criteria. The overall and recurrence-free survival rates after the LDLT were calculated. Results: The 1-, 5- and 10-year overall survival rates were 94.5%, 89.9% and 88.6%, respectively. The 1-, 5-and 10-year recurrence-free survival rates were 100%, 97.0% and 94.0%, respectively. Four patients had HCC recurrence. The mean neutrophil to lymphocyte ratio (NLR) (6.75 vs. 2.75, p=0.002) or alpha-fetoprotein (AFP) (3,239 vs. 197, p<0.001) of these four recipients was significantly higher compared to that of 125 recipients without HCC recurrence. Conclusion: The outcome of LDLT for patients with HCC within Milan criteria was outstanding. Careful follow-up after LDLT is necessary for patients with high NLR or AFP.
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页码：439 / 445
页数：7
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