Lifespan Based Pharmacokinetic-Pharmacodynamic Model of Tumor Growth Inhibition by Anticancer Therapeutics

被引:0
|
作者
Mo, Gary [1 ]
Gibbons, Frank [2 ]
Schroeder, Patricia [2 ]
Krzyzanski, Wojciech [1 ]
机构
[1] SUNY Buffalo, Buffalo, NY 14260 USA
[2] AstraZeneca R&D Boston, Waltham, MA USA
关键词
EFFICACY;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:S56 / S57
页数:2
相关论文
共 50 条
  • [41] Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel PI3K inhibitor GDC-0941
    Salphati, Laurent
    Belvin, Marcia
    Edgar, Kyle
    Prior, Wei Wei
    Sampath, Deepak
    Wallin, Jeffrey
    Wong, Harvey
    [J]. DRUG METABOLISM REVIEWS, 2009, 41 : 164 - 164
  • [42] Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941
    Salphati, Laurent
    Wong, Harvey
    Belvin, Marcia
    Bradford, Delia
    Edgar, Kyle A.
    Prior, Wei Wei
    Sampath, Deepak
    Wallin, Jeffrey J.
    [J]. DRUG METABOLISM AND DISPOSITION, 2010, 38 (09) : 1436 - 1442
  • [43] A pharmacokinetic-pharmacodynamic model predicting tumour growth inhibition after intermittent administration with the mTOR kinase inhibitor AZD8055
    Yates, James W. T.
    Holt, Sarah V.
    Logie, Armelle
    Payne, Kirsty
    Woods, Karen
    Wilkinson, Robert W.
    Davies, Barry R.
    Guichard, Sylvie M.
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (16) : 2652 - 2661
  • [44] Evaluation of pharmacokinetics of warfarin from validated pharmacokinetic-pharmacodynamic model
    Sridharan, Kannan
    Al Banna, Rashed
    Husain, Aysha
    [J]. ADMET AND DMPK, 2021, 9 (02): : 143 - 149
  • [45] A pharmacokinetic-pharmacodynamic model of acute tolerance to the subjective effects of alcohol
    Ramchandani, VA
    Hoefer, ME
    Edenberg, EF
    Walker, JT
    Hommer, DW
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2005, 29 (05) : 66A - 66A
  • [46] A pharmacokinetic-pharmacodynamic model for intrathecal baclofen in patients with severe spasticity
    Heetla, H. W.
    Proost, J. H.
    Molmans, B. H.
    Staal, M. J.
    van Laar, T.
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2016, 81 (01) : 101 - 112
  • [47] An Adaptation of the Eleveld Pharmacokinetic-Pharmacodynamic Model for a Burst Suppression Endpoint
    Lybbert, Carter
    Mickey, Brian J.
    Jones, Keith G.
    Odell, David
    Stanford, Jordan
    Tadler, Scott C.
    Huang, Jason
    Kuck, Kai
    [J]. ANESTHESIA AND ANALGESIA, 2023, 136 : 34 - 35
  • [48] Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation
    Eleveld, D. J.
    Colin, P.
    Absalom, A. R.
    Struys, M. M. R. F.
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2018, 120 (05) : 942 - 959
  • [49] Predicting Clinical Pharmacokinetics/Pharmacodynamics and Impact of Organ Impairment on siRNA-Based Therapeutics Using a Mechanistic Physiologically-Based Pharmacokinetic-Pharmacodynamic Model
    Lumen, Annie
    Zhang, Xinwen
    Dutta, Sandeep
    Upreti, Vijay V.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2024, 115 (05) : 1054 - 1064
  • [50] Physiologically based pharmacokinetic-pharmacodynamic model for capecitabine antitumor profile in colorectal cancer rats
    Sakai, Shuhei
    Kobuchi, Shinji
    Ito, Yukako
    Sakaeda, Toshiyuki
    [J]. CANCER SCIENCE, 2021, 112 : 925 - 925