Risk of second cancers after radiotherapy for cervical cancer

被引:3
|
作者
Ohno, Tatsuya
Kakinuma, Shizuko
Kato, Shingo
Tsujii, Hirohiko
Shimada, Yoshiya
机构
[1] Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 260, Japan
[2] Natl Inst Radiol Sci, Res Ctr Radiat Safey, Low Dose Radiat Effects Res Project, Chiba 260, Japan
[3] Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Sect Diag, Chiba 260, Japan
关键词
cervical cancer; epidemiology; radiotherapy; second cancer;
D O I
10.1586/14737140.6.1.49
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiotherapy for cervical cancer has both beneficial and detrimental effects: improvement of patient survival and potential induction of a second cancer among long-term survivors. Large epidemiological studies have demonstrated small, but significant, increases of second cancers with radiotherapy compared with the general population. The risk of second cancer has been characterized by organ sites, dose, time since radiotherapy and age at the time of radiotherapy. Analyses of genetic susceptibility and molecular carcinogenesis can be used to develop more appropriate strategies for radiation therapy for cervical cancers.
引用
收藏
页码:49 / 57
页数:9
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