Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma

被引：6
|
作者：
Liu, Si [1 ]
Li, Yiyang [2 ]
Xu, Hongmei [3 ]
Wang, Kaichen [4 ]
Li, Nan [5 ]
Li, Jia [6 ]
Sun, Tao [6 ]
Xu, Ying [6 ]
机构：
[1] Jilin Univ, Hosp 1, Dept Urol, Changchun Shi 130021, Jilin, Peoples R China
[2] Jilin Univ, Hosp 1, Dept Gynaecol, Changchun Shi 130021, Jilin, Peoples R China
[3] Jilin Univ, Hosp 1, Dept Obstet, Changchun 130021, Jilin, Peoples R China
[4] Jilin Univ, Hosp 3, Dept Urol, Changchun Shi 130021, Jilin, Peoples R China
[5] Jilin Univ, Hosp 1, Intens Care Unit, Changchun Shi 130021, Jilin, Peoples R China
[6] Jilin Univ, Hosp 1, Dept Nephrol, Changchun Shi 130021, Jilin, Peoples R China
来源：
BIOSCIENCE REPORTS | 2016年 / 36卷
关键词：
epigenetic; genome instability; histone; metastasis; methyltransferase; renal cell cancer; HISTONE H3; HOMOLOGOUS RECOMBINATION; PROGNOSTIC RELEVANCE; CHROMATIN-STRUCTURE; DNA-METHYLATION; METHYLTRANSFERASES; CANCER; ACETYLATION; HETEROCHROMATIN; TRANSCRIPTION;
D O I：
10.1042/BSR20160122
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that confers genomic stability. There was enhanced expression of SET domain-containing histone methyltransferases in whole lysates of all classes of renal carcinoma. In metastatic high grade clear cell carcinoma, this expression was more pronounced. Though we could not demonstrate direct correlation, we showed that epigenetic modification by methylation is associated with decreased genomic translation of Rad51.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] SET domain-containing 5 is a potential prognostic biomarker that promotes esophageal squamous cell carcinoma stemness
    Piao, Lihua
    Li, Haoyue
    Feng, Ying
    Yang, Zhaoting
    Kim, Seokhyung
    Xuan, Yanhua
    EXPERIMENTAL CELL RESEARCH, 2020, 389 (01)
  • [42] Increased expression of T cell immunoglobulin- and mucin domain-containing molecule-3 on natural killer cells in atherogenesis
    Hou, Nan
    Zhao, Di
    Liu, Ying
    Gao, Lifen
    Liang, Xiaohong
    Liu, Xiao
    Gai, Xiaoxiao
    Zhang, Xiaoning
    Zhu, Faliang
    Ni, Mei
    Zhang, Yun
    Sun, Wensheng
    Ma, Chunhong
    ATHEROSCLEROSIS, 2012, 222 (01) : 67 - 73
  • [43] Increased expression of epidermal growth factor-like domain-containing protein 7 is predictive of poor prognosis in patients with hepatocellular carcinoma
    Yang, Chao
    Wang, Yun-Liang
    Sun, Ding
    Zhu, Xiao-Li
    Li, Zhi
    Ni, Cai-Fang
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2018, 14 (04) : 867 - 872
  • [44] KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma
    Yang, Qingyuan
    Wei, Shiyin
    Qiu, Cen
    Han, Chenjie
    Du, Zunguo
    Wu, Ning
    CELL DEATH & DISEASE, 2024, 15 (12):
  • [45] The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma
    Yang Lu
    Guangda Luo
    Songbiao Zhu
    Xu Wang
    Yuling Chen
    ZhouHuan Dong
    Shiyu Wang
    Jie Ma
    Haiteng Deng
    Di Wu
    Jun Dong
    Clinical Proteomics, 2020, 17
  • [46] The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma
    Lu, Yang
    Luo, Guangda
    Zhu, Songbiao
    Wang, Xu
    Chen, Yuling
    Dong, ZhouHuan
    Wang, Shiyu
    Ma, Jie
    Deng, Haiteng
    Wu, Di
    Dong, Jun
    CLINICAL PROTEOMICS, 2020, 17 (01)
  • [47] Increased expression of FERM domain-containing 4A protein is closely associated with the development of rectal cancer
    Fan, Yongtian
    Li, Dechuan
    Qian, Jun
    Liu, Yong
    Feng, Haiyang
    Li, Dechuan
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 11 (02) : 421 - 426
  • [48] Decreased Expression of ACADSB Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
    Liu, Xianhui
    Zhang, Weiyu
    Wang, Huanrui
    Zhu, Lin
    Xu, Kexin
    FRONTIERS IN ONCOLOGY, 2022, 11
  • [49] Expression of Folate Transport Proteins are Decreased in Head and Neck Squamous Cell Carcinoma
    Green, Jacalyn M.
    Cuadros, Kayla
    Goral, Joanna
    Jham, Bruno
    Guimaraes, Eduardo Pereira
    Costa Hanneman, Joao Adolfo
    FASEB JOURNAL, 2016, 30
  • [50] High level expression of Rad51 is an independent prognostic marker of survival in non-small cell lung cancer patients
    Qiao, G
    Wu, Y
    Yang, X
    Zhong, W
    Xie, D
    Guan, X
    Stuerzbecher, H
    LUNG CANCER, 2005, 49 : S45 - S45
12345