Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles

被引：1

作者：

Pati, Soumyaranjan ^{[1
]}

Almeida, Renata G. ^{[2
]}

da Silva Junior, Eufranio N. ^{[2
]}

Namboothiri, Irishi N. N. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India

[2] Univ Fed Minas Gerais, Inst Exact Sci, Dept Chem, BR-31270901 Belo Horizonte, MG, Brazil

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷

关键词：

azoles; cycloaddition; enones; heterocycles; 1,2,3-triazoles;

D O I：

10.3762/bjoc.17.66

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Desulfonylative alkylation of N-tosyl-1,2,3-triazoles under metal-free conditions leading to beta-triazolylenones is reported here. The present study encompasses the synthesis of triazoles with a new substitution pattern in a single step from cyclic 1,3-dicarbonyl compounds and N-tosyl triazole in moderate to high yields. Our synthesis takes place with complete regioselectivity as confirmed by crystallographic analysis which is rationalized by a suitable mechanistic proposal. This method provides an efficient, versatile and straightforward strategy towards the synthesis of new functionalized 1,2,3-triazoles.

引用

页码：762 / 770

页数：9

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