Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients

被引：20
|
作者：
Rak, Jakub [1 ]
Kaplanek, Robert [1 ]
Kral, Vladimir [1 ]
机构：
[1] Inst Chem Technol, Dept Analyt Chem, CR-16628 Prague 6, Czech Republic
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 03期
关键词：
Cobalt bis(dicarbollide); Metallacarborane; Excipient; Solubilization; Deaggregation; Cyclodextrin; Surfactant; BETA-CYCLODEXTRIN; HIV PROTEASE; LIGHT-SCATTERING; BORON CLUSTERS; METALLACARBORANES; CHEMISTRY; BACTERIOCHLORIN; COMPLEXATION; INHIBITORS; CARBORANE;
D O I：
10.1016/j.bmcl.2009.12.038
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1045 / 1048
页数：4
相关论文
共 50 条
  • [41] Computational study of structures and properties of metallaboranes:: Cobalt bis(dicarbollide)
    Bühl, M
    Hnyk, D
    Machacek, J
    CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (14) : 4109 - 4120
  • [42] Raman studies of TMTSF salt of cobalt bis(dicarbollide) anion
    Barszcz, B.
    Graja, A.
    Ziolkovskiy, D. V.
    Starodub, V. A.
    Kravchenko, A. V.
    JOURNAL OF MOLECULAR STRUCTURE, 2010, 976 (1-3) : 196 - 199
  • [43] Synthesis of crown ethers with the incorporated cobalt bis(dicarbollide) fragment
    Kazakov, Grigoriy S.
    Stogniy, Marina Yu.
    Sivaev, Igor B.
    Suponitsky, Kyrill Yu.
    Godovikov, Ivan A.
    Kirilin, Alexey D.
    Bregadze, Vladimir I.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2015, 798 : 196 - 203
  • [44] Synthesis and Structure of Methylsulfanyl Derivatives of Nickel Bis(Dicarbollide)
    Anufriev, Sergey A.
    Suponitsky, Kyrill Yu
    Filippov, Oleg A.
    Sivaev, Igor B.
    MOLECULES, 2019, 24 (24):
  • [45] A Simple Way to Obtain a Decachloro Derivative of Cobalt Bis(dicarbollide)
    Anufriev, Sergey A.
    Stogniy, Marina Yu.
    Sivaev, Igor B.
    REACTIONS, 2023, 4 (01): : 148 - 154
  • [46] Synthesis of cobalt dicarbollide derivatives for addition and condensation polymerization.
    Balaich, GJ
    Miller, RL
    Abney, KD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 390 - INOR
  • [47] THE SYNTHESIS, CHARACTERIZATION AND STRUCTURE OF CHLORINATED DERIVATIVES OF THE COBALT DICARBOLLIDE ANION
    HURLBURT, PK
    KINKEAD, SA
    FOREMAN, TM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 507 - INOR
  • [48] Synthesis and cytotoxicity of novel cholesterol-cobalt bis(dicarbollide) conjugates
    Druzina, Anna A.
    Dudarova, Nadezhda, V
    Zhidkova, Olga B.
    Razumov, Ivan A.
    Solovieva, Olga I.
    Kanygin, Vladimir V.
    Bregadze, Vladimir I.
    MENDELEEV COMMUNICATIONS, 2022, 32 (03) : 354 - 356
  • [49] Structure of new organic semiconductors with cobalt bis(dicarbollide) bromine anion
    Kazheva, Olga
    Alexandrov, Grigorii
    Dyachenko, Oleg
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 : C466 - C466
  • [50] Synthesis of cobalt bis(dicarbollide) conjugates with natural chlorins by the Sonogashira reaction
    Grin, M. A.
    Titeev, R. A.
    Brittal, D. I.
    Chestnova, A. V.
    Feofanov, A. V.
    Lobanova, I. A.
    Sivaev, I. B.
    Bregadze, V. I.
    Mironov, A. F.
    RUSSIAN CHEMICAL BULLETIN, 2010, 59 (01) : 219 - 224
12345