SPECTROPHOTOMETRIC STUDY OF STABILITY CONSTANTS OF FAMOTIDINE-Cu(II) COMPLEX AT DIFFERENT TEMPERATURES

被引：0

作者：

Tirmizi, Syed Ahmad ^{[3
]}

Wattoo, Muhammad Hamid Sarwar ^{[3
]}

Sarwar, Saadia ^{[3
]}

Anwar, Waheed ^{[3
]}

Wattoo, Feroza Hamid ^{[1
]}

Memon, Allah Nawaz ^{[1
]}

Iqbal, Javed ^{[2
]}

机构：

[1] Univ Sindh, Inst Biochem, Jamshoro 76080, Pakistan

[2] Univ Punjab, Inst Chem, Lahore 54590, Pakistan

[3] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

来源：

ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING | 2009年 / 34卷 / 2A期

关键词：

famotidine; copper; spectrophotometry; stability constant; VALIDATION; DRUG;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Famotidine is an effective inhibitor of gastric acid secretions. The formation of copper(H) complex with famotidine has been studied spectrophotometrically at an absorption maximum of 638 nm at different temperatures. The data shows that copper(H) and famotidine combine in the molar ratio of 1: 1 at pH 5.0. The stability constants of the complex were calculated to be 2.55 x 10(4), 2.38 x 10(4), and 2.50 x 10(4) by continuous variation method and 1.31 x 10(4), 1.31 x 10(4), and 1.26 x 10(4) by mote ratio method at 25, 40, and 50 degrees C, respectively.

引用

页码：43 / 48

页数：6

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