Specific detection of Epstein-Barr virus in inflammatory pseudotumor of the spleen in a patient with a high serum level of soluble IL-2 receptor

被引：20
|
作者：
Yamaguchi, M [1 ]
Yamamoto, T [1 ]
Tate, G [1 ]
Matsumoto, T [1 ]
Matsumiya, A [1 ]
Kuzume, M [1 ]
Sanada, Y [1 ]
Kumada, K [1 ]
机构：
[1] Showa Univ, Fujigaoka Hosp, Dept Surg, Aoba Ku, Yokohama, Kanagawa 2278501, Japan
来源：
JOURNAL OF GASTROENTEROLOGY | 2000年 / 35卷 / 07期
关键词：
spleen; inflammatory pseudotumor; Epstein-Barr virus; soluble interleukin-2 receptor;
D O I：
10.1007/s005350070082
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A case of inflammatory pseudotumor of the spleen is described in a 63-year-old woman who presented with an intrasplenic tumor and an elevated serum level of soluble interleukin 2 receptor (sIL-2R). Microscopic examination after removal of the spleen revealed that the tumor was composed of mixed cellular infiltrates, mainly lymphocytes and plasma cells, and spindle-cell proliferation. Epstein-Barr virus (EBV) was specifically detected in the tumor by in situ hybridization for EBV RNA. The serum level of sIL-2R level was normalized after splenectomy. EBV infection may play a role in the development of splenic inflammatory pseudotumor and the elevation of sIL-2R level.
引用
收藏
页码：563 / 566
页数：4
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