Chiron approaches to polyhydroxylated piperidines: promising glycosidase inhibitors

被引：14
|
作者：
Dhavale, DD [1 ]
Desai, VN [1 ]
Saha, NN [1 ]
Tilekar, JN [1 ]
机构：
[1] Univ Pune, Dept Chem, Garware Res Ctr, Pune 411007, Maharashtra, India
来源：
ARKIVOC | 2002年
关键词：
alkaloids; piperidines; nitrone; reductive amination; conjugate addition; enzyme inhibitors;
D O I：
10.3998/ark.5550190.0003.711
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New chiron approaches towards the syntheses of polyhydroxylated piperidine analogues are described. The methodologies involve 1,3-addition of methyl magnesium bromide and silyl ketene acetal to D-glucose derived nitrone, intramolecular Michael addition to D- glucose derived alpha, beta-unsaturated ester and double reductive amination of 5-keto aldose as key steps.
引用
收藏
页码：91 / 105
页数：15
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