Chiron approaches to polyhydroxylated piperidines: promising glycosidase inhibitors

被引：14

作者：

Dhavale, DD ^{[1
]}

Desai, VN ^{[1
]}

Saha, NN ^{[1
]}

Tilekar, JN ^{[1
]}

机构：

[1] Univ Pune, Dept Chem, Garware Res Ctr, Pune 411007, Maharashtra, India

来源：

ARKIVOC | 2002年

关键词：

alkaloids; piperidines; nitrone; reductive amination; conjugate addition; enzyme inhibitors;

D O I：

10.3998/ark.5550190.0003.711

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New chiron approaches towards the syntheses of polyhydroxylated piperidine analogues are described. The methodologies involve 1,3-addition of methyl magnesium bromide and silyl ketene acetal to D-glucose derived nitrone, intramolecular Michael addition to D- glucose derived alpha, beta-unsaturated ester and double reductive amination of 5-keto aldose as key steps.

引用

页码：91 / 105

页数：15

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